IGF::OT::IGF BLSA

巴尔的摩老龄化纵向研究 (BLSA) 由 NIA 校内研究计划的研究人员进行。 BLSA 是美国历史最悠久的人类衰老科学研究项目。超过 1,250 名男性和女性（年龄从 20 多岁到 90 多岁）积极参与这项研究，参与人数超过 3000 人。自 1958 年成立以来，BLSA 不仅在正常衰老过程方面取得了许多发现，而且还阐明了疾病对正常衰老过程的影响。最近，BLSA 正在收集数据，探索导致身体和认知功能随着衰老而下降的多因素途径。 2002-2003 年，NIA 研究人员为 BLSA 的科学议程制定了新的框架。虽然该研究将保留其许多研究目的和目标，但研究人员计划重点关注未来招募“成功的老年人”，或75岁时很少（如果有的话）与年龄相关的疾病或残疾的人。这将使该研究能够更深入地调查整个生命周期中预测健康衰老和健康相关结果的因素，确定成功适应衰老的策略，并就可能积极影响特定衰老表型和预防与年龄相关的疾病的可能干预目标提出假设。此外，BLSA 研究人员正在努力促进横断面和纵向分析，这将增加我们对各种参数的变化如何影响衰老、年龄相关疾病以及虚弱和残疾的发展的理解。 NIA 研究人员还进行小型、集中和深入的临床研究，旨在测试 BLSA 背景下提出的一些假设，并利用转化研究部分促进其临床转化。

The Baltimore Longitudinal Study on Aging (BLSA) is conducted by investigators in the NIA Intramural Research Program. The BLSA is America's longest-running scientific study of human aging. More than 1,250 men and women, ranging in age from the twenties to the nineties, are active participants in this study from more of 3000 that were enrolled. Since its inception in 1958, the BLSA has generated numerous findings not only on the normal course of aging, but also disentangling the effects of disease from the normal aging process. More recently, the BLSA is collecting data that explore the multifactorial pathways that lead to decline of physical and cognitive function with aging. In 2002-2003 NIA investigators produced a new framework for the BLSA¿s scientific agenda. While the study will retain many of its research goals and objectives, the investigators plan to place a strong emphasis on future recruitment of ¿successful agers,¿ or those who at age 75 have few, if any, age-associated diseases or disabilities. This will permit the study to more intensely investigate factors that predict healthy aging and health-related outcomes across the life-span, to identify strategies for successful adaptation to aging, and to develop hypotheses concerning possible targets for intervention that may positively affect specific aging phenotypes and prevent age-related diseases. In addition, BLSA investigators are working to facilitate cross-sectional and longitudinal analyses that will increase our understanding of how changes in various parameters affect aging, age-related disease, and the development of frailty and disability. NIA investigators also conduct small, focused and in depth clinical studies aimed at testing some of the hypotheses developed in the context of the BLSA, and facilitate their clinical translation using the Translational Research Section.