ESTABLISHING OUTCOMES FOR THE BALTIMORE LONGITUDINAL STUDY OF AGING COHORT. THE

对由于不同原因不能来巴尔的摩研究诊所进行传统随访评估的BLSA参与者进行家访。最初，这些访问将包括481名目前不活跃但从未正式退出研究的BLSA参与者。预计在5年的随访中，除了第一年预计有125名符合条件的参与者外，每年平均有150名参与者有资格参加家访计划。家访应按照BLSA对研究诊所的定期访问时间表进行（60岁以下的参与者每4年一次，60-79岁的参与者每两年一次，80岁及以上的参与者每年一次）。主要目标是：对不能来巴尔的摩进行传统评估的BLSA参与者进行随访评估；制定结果衡量标准，最大限度地科学利用先前在这些参与者中收集的大量数据；减少“信息审查”的偏颇效应，增加研究价值；扩大对已出现严重合并症和残疾的参与者的生物样本收集；获得参与者的知情同意，使用他们之前捐赠给研究的生物样本来解决新的研究问题。

To perform home-based visits in the BLSA participants who, for different reasons, cannot come to the study clinic in Baltimore for a traditional follow-up evaluation. Initially, these visits will include 481 BLSA participants who are currently inactive but never officially dropped out of the study. It is expected that an average of 150 participants will become eligible for the home visit program for each of the 5 years of follow-up, except for the first year when it is expected to have 125 eligible participants. Home visits shall be performed following the schedule specified for regular BLSA visits to the study clinic (every 4 years for participants less than 60 years old, every two years for 60-79 and annually for 80 and older). The main objectives are to: perform follow-up evaluations of BLSA participants who cannot come to Baltimore for a traditional assessment in the study dinic; create outcome measures that maximize the scientific use of the extensive data previously collected in these participants; increase the value of the study by reducing the biasing effect of "informative censoring"; expand the collection of biological samples in participants who have developed substantial comorbidity and disability; obtain informed consent from participants for the use of biological samples that they previously donated to the study to address new research questions.