课题基金 / 基金详情

Allergen and T-Cell Reagent Resources for the Study of Allergic Diseases

Allergen and T-Cell Reagent Resources for the Study of Allergic Diseases
用于过敏性疾病研究的过敏原和 T 细胞试剂资源
批准号：
8317525
负责人：
William W. Kwok
金额：
$218.94万
依托单位：
BENAROYA RESEARCH INST AT VIRGINIA MASON
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
项目状态：
已结题
起止时间：
2007-09-28 至 2012-09-27
来源：
https://reporter.nih.gov/project-details/8317525
关键词：
AffinityAlder plantAllergensAllergic DiseaseAllergic rhinitisAsthmaBetula GenusBindingCD4 Positive T LymphocytesCell LineContractorCore FacilityCynodonDiseaseEpitopesFelis catusFood HypersensitivityFrequenciesGoalsMHC Class II GenesMethodsPeanuts - dietaryPeptidesPhenotypePhleumReagentRegulatory T-LymphocyteResearchResourcesSourceSupport ContractsT-LymphocyteT-Lymphocyte EpitopesTechniquesVenomsYellow Jacketsanergycytokinefungusinnovationnovelvaccine development

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中文摘要
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英文摘要
This contract supports two distinct objectives. The first objective is to support core facilities that will use innovative isolation and purification techniques to identify novel allergens associated with allergic diseases including asthma and allergic rhinitis, from various sources. The second objective is to identify and characterize peptides containing T cell epitopes that induce anergy in allergen-specific effector T cells, or activate allergen-specific regulatory T cells. The major goals of this initiative are to identify novel allergens using innovative purification methods, and to generate a set of defined peptides that regulate the function of allergen-specific effector and regulatory T cells.
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