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Identifying Epitopes Recognized by Influenza and Flavivirus.

Identifying Epitopes Recognized by Influenza and Flavivirus.
鉴定流感和黄病毒识别的表位。
批准号：
8877353
负责人：
William W. Kwok
金额：
$44.04万
依托单位：
BENAROYA RESEARCH INST AT VIRGINIA MASON
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-09-30 至 2014-09-29
来源：
https://reporter.nih.gov/project-details/8877353
关键词：
AcuteAmino AcidsAvian InfluenzaBioterrorismCD4 Positive T LymphocytesCapsidComplexDengue VirusDetectionDiagnosticEmerging Communicable DiseasesEpitope MappingEpitopesFlavivirusGenerationsGenesGoalsHaplotypesHemagglutininHumanImmuneImmunityIndividualInfectionInfluenzaInfluenza A virusIntegral Membrane ProteinJapanese encephalitis virusLengthLigandsMaintenanceNeuraminidasePeptide/MHC ComplexPeptidesPeripheral Blood Mononuclear CellPolymerasePreventionProductionProteinsRNARecording of previous eventsStaining methodStainsT-Cell ActivationT-LymphocyteT-Lymphocyte EpitopesTherapeuticToxinTranscriptValidationVirusVirus DiseasesWest Nile virusYellow fever virusbasecytokinedesignenv Gene Productsimprovedmicroorganismmultiple myeloma M Proteinnovelprogramsseasonal influenzatoolvaccine development

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中文摘要
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英文摘要
The goal of the Large Scale T Cell Epitope Discovery program is to establish and support several highly interactive, multi-disciplinary teams focused on large scale discovery of T cell epitopes associated with microorganisms responsible for emerging and re-emerging infectious diseases and potential agents of bioterrorism and their toxins. The discovery and validation of novel T cell epitopes will facilitate the design and development of vaccines; improved immune-based therapeutics; and diagnostic tools for the prevention, treatment and detection of such infections, by providing critical information needed to select MHC-peptide or other MHC-ligand complexes that induce T cell activation for the generation and maintenance of protective immunity.
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