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Identifying Epitopes Recognized by Influenza and Flavivirus.

Identifying Epitopes Recognized by Influenza and Flavivirus.
鉴定流感和黄病毒识别的表位。
批准号：
8877353
负责人：
William W. Kwok
金额：
$44.04万
依托单位：
BENAROYA RESEARCH INST AT VIRGINIA MASON
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-09-30 至 2014-09-29
来源：
https://reporter.nih.gov/project-details/8877353
关键词：
AcuteAmino AcidsAvian InfluenzaBioterrorismCD4 Positive T LymphocytesCapsidComplexDengue VirusDetectionDiagnosticEmerging Communicable DiseasesEpitope MappingEpitopesFlavivirusGenerationsGenesGoalsHaplotypesHemagglutininHumanImmuneImmunityIndividualInfectionInfluenzaInfluenza A virusIntegral Membrane ProteinJapanese encephalitis virusLengthLigandsMaintenanceNeuraminidasePeptide/MHC ComplexPeptidesPeripheral Blood Mononuclear CellPolymerasePreventionProductionProteinsRNARecording of previous eventsStaining methodStainsT-Cell ActivationT-LymphocyteT-Lymphocyte EpitopesTherapeuticToxinTranscriptValidationVirusVirus DiseasesWest Nile virusYellow fever virusbasecytokinedesignenv Gene Productsimprovedmicroorganismmultiple myeloma M Proteinnovelprogramsseasonal influenzatoolvaccine development

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中文摘要
翻译
大规模T细胞表位发现项目的目标是建立和支持几个高度互动的多学科团队，专注于大规模发现与新出现和再出现的传染病和生物恐怖主义潜在病原体及其毒素相关的微生物的T细胞表位。新的T细胞表位的发现和验证将促进疫苗的设计和开发；改进的免疫疗法；以及用于预防、治疗和检测此类感染的诊断工具，通过提供选择诱导T细胞激活的mhc肽或其他mhc配体复合物所需的关键信息，以产生和维持保护性免疫。
英文摘要
The goal of the Large Scale T Cell Epitope Discovery program is to establish and support several highly interactive, multi-disciplinary teams focused on large scale discovery of T cell epitopes associated with microorganisms responsible for emerging and re-emerging infectious diseases and potential agents of bioterrorism and their toxins. The discovery and validation of novel T cell epitopes will facilitate the design and development of vaccines; improved immune-based therapeutics; and diagnostic tools for the prevention, treatment and detection of such infections, by providing critical information needed to select MHC-peptide or other MHC-ligand complexes that induce T cell activation for the generation and maintenance of protective immunity.
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