Breast Cancer Family Registry Cohort

乳腺癌家族登记队列

• 批准号: 8374040
• 负责人: Irene Andrulis
• 金额: $ 272.31万
• 依托单位: CANCER PREVENTION INSTIT OF CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-12 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8374040
• 关键词: Affect; Behavior Therapy; Behavioral; Breast; Cancer Prevention Trial; Clinical; Clinical Research; Collaborations; Collection; Communication; Data; Epidemiology; Family; Family Cancer History; Family member; Genetic screening method; Genotype; Health behavior; Hereditary Breast Carcinoma; Hereditary Disease; Immunohistochemistry; Individual; International; Knowledge; Malignant Neoplasms; Molecular; Molecular Genetics; Outcome; Pathology; Predisposition; Preventive; Prospective Studies; Protocols documentation; Questionnaires; Recording of previous events; Recurrence; Research; Research Infrastructure; Research Personnel; Resources; Risk; Risk Factors; Scientist; Screening procedure; Site; Specimen; Translations; Tumor Subtype; Update; Variant; Woman; base; breast cancer family; breast cancer family registry; cancer risk; clinical practice; cohort; epidemiologic data; follow-up; gene discovery; high risk; insight; instrument; malignant breast neoplasm; member; men; translational study; tumor; uptake

DESCRIPTION (provided by applicant): The objective of this UM1 application is to maintain and enhance the core infrastructure of the Breast Cancer Family Registry (BCFR), an international resource of multi-generational families established for interdisciplinary collaboratie research on breast cancer. The BCFR Cohort, established in 1995 at 6 sites is comprised of 34,000 individuals from 11,900 families who provided data on family history and epidemiologic risk factors as well as bio specimens. Over the next five years, the BCFR investigator team will continue 1) to actively follow the family cohort using common instruments and protocols, update the cancer family histories to identify new breast and other cancers in the families, and administer a follow-up questionnaire to update baseline epidemiologic data; 2) to maintain the extensive data and bio specimen resources and enhance them by conducting pathology review for all new breast cancers ascertained since baseline, completing molecular sub typing of tumors, and completing genotyping of known common breast cancer susceptibility variants; 3) to collect new data on screening, uptake of risk reductive and preventive health behaviors, knowledge of genetic disease, and uptake of genetic testing and communication to family members that will facilitate the translation of findings into clinical practice; and 4) to continue and expand collaborations with external investigators by sharing of BCFR data and bio specimen resources for a wide range of studies of gene discovery, cancer-related outcomes, risk factors in high-risk individuals, behavioral interventions and cancer prevention trials among at-risk family members. The BCFR Cohort is unique in that it is family-based and the first large prospective study of breast cancer risk for women at a continuum of risk. In addition to the unaffected cohort, the BCFR has one of the largest affected cohorts and will therefore provide a powerful resource for translational and clinical studies of recurrences, second primaries and survival.

描述（由申请人提供）：UM 1申请的目的是维护和加强乳腺癌家庭登记处（BCFR）的核心基础设施，这是一个为乳腺癌跨学科合作研究而建立的多代家庭的国际资源。BCFR队列研究于1995年在6个研究中心建立，由来自11，900个家庭的34，000名个体组成，他们提供了家族史和流行病学风险因素以及生物标本的数据。在接下来的五年里，BCFR研究团队将继续1）使用通用工具和方案积极跟踪家庭队列，更新癌症家族史以确定家庭中的新乳腺癌和其他癌症，并进行随访问卷调查以更新基线流行病学数据; 2）维护广泛的数据和生物样本资源，并通过对自基线以来确定的所有新发乳腺癌进行病理学审查，完成肿瘤的分子亚型分型，并完成已知常见乳腺癌易感性变异的基因分型; 3）收集有关筛查、采取风险降低和预防性健康行为、遗传疾病知识以及采取基因检测和与家庭成员沟通的新数据，以促进将结果转化为临床实践;以及4）继续 通过共享BCFR数据和生物标本资源，扩大与外部研究人员的合作，用于基因发现、癌症相关结局、高危个体风险因素、行为干预和高危家庭成员癌症预防试验等广泛研究。BCFR队列的独特之处在于它是以家庭为基础的，并且是第一个针对处于连续风险的女性乳腺癌风险的大型前瞻性研究。除了未受影响的队列外，BCFR还拥有最大的受影响队列之一，因此将为复发、第二原发和生存的转化和临床研究提供强大的资源。