Optimizing microwave ablation techniques for targeted cancer therapy

优化微波消融技术以进行癌症靶向治疗

• 批准号: 8206684
• 负责人: Christopher L Brace
• 金额: $ 28.41万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8206684
• 关键词: Ablation; Adoption; Affect; Algorithms; Area; Blood flow; Body part; Cancerous; Clinic; Clinical; Clinical Trials; Cryosurgery; Data; Development; Devices; Electric Conductivity; Engineering; Equipment; Frequencies; Growth; Heating; Histocompatibility Testing; Human; Hybrids; Image; Knowledge; Lasers; Liver; Lung; Medical; Medicine; Modality; Modeling; Monitor; Operative Surgical Procedures; Patient Care; Patients; Performance; Phase; Physiologic pulse; Plague; Preclinical Testing; Procedures; Property; Puncture procedure; Radiofrequency Interstitial Ablation; Recurrence; Reporting; Role; Source; Specificity; Speed; System; Techniques; Technology; Thermal Ablation Therapy; Time; Tissue Model; Tissues; Translations; Treatment Efficacy; Treatment Protocols; base; bone; cancer care; cancer therapy; clinical efficacy; clinical practice; clinically relevant; cryogenics; design; experience; improved; industry partner; innovation; interstitial; killings; microwave electromagnetic radiation; minimally invasive; oncology; patient population; public health relevance; radiofrequency; simulation; stem; therapy design; tool; tumor

DESCRIPTION (provided by applicant): The long-term objective of this project is to improve devices and techniques for microwave tumor ablation and extend its application into new patient populations by optimizing system design and energy delivery in several tissue types. Microwave ablation is superior to currently available technologies in many respects: microwaves provide rapid volumetric heating, leading to more precise and complete treatments; microwave heating is less dependent on tissue properties, making it more suitable for emerging targets (e.g., lung and bone); and using multiple antennas improves treatment control, precision and efficacy. Unfortunately, current systems have failed to deliver on these promises and patients who could benefit from improved therapies have suffered. This proposal is based on the idea that understanding more about microwave tissue heating will facilitate development of optimized systems and techniques that will enhance patient benefit and expand the role of microwave ablation in cancer care. As microwave ablation systems begin to enter the marketplace, optimized treatment protocols will be required to enhance patient benefit and expand the role of microwave ablation in clinical cancer care. To this end, we propose to: 1) Create improved numerical models of tissue to more accurately predict device performance. Hypothesis: Accurate tissue models improve numerical simulations, easing design and treatment optimization. 2) Optimize antenna designs and power delivery for tissue-specific treatments Hypotheses: Antenna design and frequencies can be optimized for specific tissues or treatment targets. Applying high-power pulses will more rapidly coagulate tissue microvasculature to improve efficacy. When combined, these optimizations will create ablations 50% faster and 25% larger than current systems. 3) Develop multiple-antenna application techniques to optimize treatment speed and specificity. Hypotheses: Multiple-antenna techniques improve efficacy and precision, allowing more tailored treatments without increasing invasiveness. Ablations can be created by 50% faster and 40% larger than current systems. 4) Facilitate real-time adaptive power control by using integrated treatment monitoring Hypothesis: Treatment monitoring can be accomplished without imaging, using only the interstitial applicator. If successful, this project will advance knowledge of microwave tissue heating, and create innovative and unique approaches to power delivery that utilize all of the advantages that microwaves offer. These aims will substantially change clinical practice by increasing the size of tumors that can be treated with microwaves, further broadening the scope of microwave ablation to areas outside the liver and increasing the number of patients benefiting from minimally invasive treatments. PUBLIC HEALTH RELEVANCE: This proposal will combine the best of engineering and medicine to better understand how ablations are created, develop tools for improved system design, and create a cancer treatment platform that requires minimal invasiveness to provide maximal patient benefit.

描述（由申请人提供）： 该项目的长期目标是改进微波肿瘤消融的设备和技术，并通过优化系统设计和多种组织类型的能量输送将其应用扩展到新的患者群体。微波消融在许多方面优于现有技术：微波提供快速的体积加热，从而实现更精确和完整的治疗；微波加热对组织特性的依赖性较小，使其更适合新兴目标（例如肺和骨骼）；使用多个天线可以提高治疗控制、精度和功效。不幸的是，当前的系统未能兑现这些承诺，本来可以从改进的疗法中受益的患者却遭受了痛苦。 该提案基于这样的想法：更多地了解微波组织加热将有助于开发优化的系统和技术，从而提高患者的利益并扩大微波消融在癌症护理中的作用。随着微波消融系统开始进入市场，需要优化治疗方案以提高患者利益并扩大微波消融在临床癌症护理中的作用。为此，我们建议：1）创建改进的组织数值模型，以更准确地预测设备性能。假设：准确的组织模型可以改善数值模拟，简化设计和治疗优化。 2) 针对特定组织治疗优化天线设计和功率传输 假设：可以针对特定组织或治疗目标优化天线设计和频率。应用高功率脉冲将更快地凝固组织微血管以提高疗效。结合起来，这些优化将比当前系统产生的消融速度快 50%，面积大 25%。 3) 开发多天线应用技术以优化治疗速度和特异性。假设：多天线技术可提高疗效和精确度，从而在不增加侵入性的情况下实现更量身定制的治疗。与当前系统相比，消融的创建速度快 50%，面积大 40%。 4) 通过使用集成治疗监测促进实时自适应功率控制 假设：无需成像，仅使用间隙施放器即可完成治疗监测。 如果成功，该项目将推进微波组织加热的知识，并创造创新和独特的电力传输方法，利用微波提供的所有优势。这些目标将通过增加可以用微波治疗的肿瘤的大小、进一步将微波消融的范围扩大到肝脏以外的区域以及增加受益于微创治疗的患者数量来显着改变临床实践。 公共卫生相关性： 该提案将结合最好的工程和医学，以更好地了解消融是如何创建的，开发改进系统设计的工具，并创建一个需要最小侵入性以提供最大患者利益的癌症治疗平台。