Developing microwave epiphysiodesis to correct limb length discrepancies

开发微波骨骺固定术以纠正肢体长度差异

• 批准号: 10804031
• 负责人: Christopher L Brace
• 金额: $ 47.33万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-25 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10804031
• 关键词: Abdomen; Ablation; Address; Adoption; Algorithms; Animal Model; Arthritis; Benign; Biological; Bone Growth; Canis familiaris; Chest; Child; Clinical; Curettage procedure; Data; Deformity; Development; Devices; Disease; Distal; Dose Rate; Elements; Ensure; Epiphysial cartilage; Equilibrium; Excision; Family suidae; Femur; Fracture; Frequencies; Gait; Geometry; Growth; Heating; Hemorrhage; Human; Incidence; Infection; Intervention; Joints; Lead; Left; Leg; Length; Limb structure; Malignant - descriptor; Mechanics; Microwave Tumor Ablation; Morbidity - disease rate; Necrosis; Operative Surgical Procedures; Oryctolagus cuniculus; Pain; Patients; Positioning Attribute; Post-Procedural Pain; Procedures; Quality of life; Radiofrequency Interstitial Ablation; Recovery; Reproducibility; Safety; Shapes; System; Techniques; Technology; Temperature; Tissues; Translating; Translations; Traumatic injury; Weight-Bearing state; articular cartilage; bone; chronic back pain; clinical translation; design; direct application; fibula; follow-up; insight; microwave ablation; microwave electromagnetic radiation; novel; pediatric patients; preclinical study; prevent; psychologic; research clinical testing; side effect; stem; tibia; treatment optimization; tumor; tumor ablation; tumor eradication

PROJECT ABSTRACT This project addresses a need for less morbid alternatives to surgical drilling of growth plates in the treatment of limb length discrepancies. Surgical approaches currently require 6 weeks of recovery before weight bearing, which takes a physical and psychological toll on pediatric patients. Surgery has also been associated with complications such as incomplete growth arrest, angular deformity, bleeding, and infection. We hypothesize that microwave ablation – a technology already used for treating malignant and benign tumors throughout the body, including in bones – can be used to disrupt the growth plate with fewer complications and faster return to baseline activity. Preliminary data demonstrates the feasibility delivering microwave energy to create heating in the growth plate when using clinical microwave tumor ablation systems in porcine tibias. This project will focus on developing more optimal devices and techniques for growth plate ablation. Directional antennas will be developed that target microwave energy to the growth plate while minimizing collateral damage. Dynamic positioning and multi-applicator techniques will be used to further refine energy delivery to ensure complete and uniform growth arrest. Finally, the safety and efficacy of the optimized techniques will be compared against the gold-standard of surgical drilling in distal femur, proximal tibia, and fibula. If successful, these developments and studies will form the basis for a novel and exciting treatment for limb length discrepancy in children.

项目摘要 该项目解决了治疗中对生长板的外科手术钻孔的需求较小的需求 肢体长度差异。目前，手术方法需要在负重之前进行6周的恢复， 这给小儿患者造成了身体和心理伤害。手术也与 并发症，例如不完整的生长停滞，角畸形，出血和感染。我们假设 微波炉消融 - 一种已经用于治疗整个整个过程中的恶性和良性肿瘤的技术 身体，包括骨头 - 可用于破坏生长板的并发症较少，然后更快地返回 基线活动。初步数据表明可行性可提供微波能量以创建加热 在猪胫骨中使用临床微波肿瘤消融系统时，生长板。这个项目将集中 为了开发更佳的生长板消融设备和技术。定向天线将是 将该小波能量靶向生长板，同时最大程度地减少附带损害。动态的 定位和多启示器技术将用于进一步完善能源传递以确保完成 和统一的生长停滞。最后，将优化技术的安全性和效率与 股骨远端，胫骨和腓骨的手术钻孔的金色标准。如果成功，这些 发展和研究将构成新颖而令人兴奋的肢体长度差异的基础 孩子们。