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Developing microwave epiphysiodesis to correct limb length discrepancies

开发微波骨骺固定术以纠正肢体长度差异

基本信息

批准号：
10804031
负责人：
Christopher L Brace
金额：
$ 47.33万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-25 至 2028-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10804031
关键词：
Abdomen Ablation Address Adoption Algorithms Animal Model Arthritis Benign Biological Bone Growth Canis familiaris Chest Child Clinical Curettage procedure Data Deformity Development Devices Disease Distal Dose Rate Elements Ensure Epiphysial cartilage Equilibrium Excision Family suidae Femur Fracture Frequencies Gait Geometry Growth Heating Hemorrhage Human Incidence Infection Intervention Joints Lead Left Leg Length Limb structure Malignant - descriptor Mechanics Microwave Tumor Ablation Morbidity - disease rate Necrosis Operative Surgical Procedures Oryctolagus cuniculus Pain Patients Positioning Attribute Post-Procedural Pain Procedures Quality of life Radiofrequency Interstitial Ablation Recovery Reproducibility Safety Shapes System Techniques Technology Temperature Tissues Translating Translations Traumatic injury Weight-Bearing state articular cartilage bone chronic back pain clinical translation design direct application fibula follow-up insight microwave ablation microwave electromagnetic radiation novel pediatric patients preclinical study prevent psychologic research clinical testing side effect stem tibia treatment optimization tumor tumor ablation tumor eradication

项目摘要

PROJECT ABSTRACT This project addresses a need for less morbid alternatives to surgical drilling of growth plates in the treatment of limb length discrepancies. Surgical approaches currently require 6 weeks of recovery before weight bearing, which takes a physical and psychological toll on pediatric patients. Surgery has also been associated with complications such as incomplete growth arrest, angular deformity, bleeding, and infection. We hypothesize that microwave ablation – a technology already used for treating malignant and benign tumors throughout the body, including in bones – can be used to disrupt the growth plate with fewer complications and faster return to baseline activity. Preliminary data demonstrates the feasibility delivering microwave energy to create heating in the growth plate when using clinical microwave tumor ablation systems in porcine tibias. This project will focus on developing more optimal devices and techniques for growth plate ablation. Directional antennas will be developed that target microwave energy to the growth plate while minimizing collateral damage. Dynamic positioning and multi-applicator techniques will be used to further refine energy delivery to ensure complete and uniform growth arrest. Finally, the safety and efficacy of the optimized techniques will be compared against the gold-standard of surgical drilling in distal femur, proximal tibia, and fibula. If successful, these developments and studies will form the basis for a novel and exciting treatment for limb length discrepancy in children.

项目摘要