Developing microwave epiphysiodesis to correct limb length discrepancies

项目摘要 该项目解决了需要较少的病态替代手术钻孔生长板在治疗 肢体长度的差异手术方法目前需要6周的恢复才能承重， 这会给儿科患者带来身心上的伤害手术也与 并发症如不完全生长停止、成角畸形、出血和感染。我们假设 微波消融-一种已经用于治疗恶性和良性肿瘤的技术， 身体（包括骨骼）可用于破坏生长板，并发症更少，恢复速度更快 基线活动。初步数据表明，通过输送微波能量来加热空气是可行的。 当在猪胫骨中使用临床微波肿瘤消融系统时，生长板。该项目将重点 开发更优化的生长板消融设备和技术。定向天线将在 将微波能量瞄准生长板，同时将附带损害降至最低。动态 将使用定位和多施源器技术来进一步改进能量输送， 和均匀的生长停滞。最后，将比较优化技术的安全性和有效性， 股骨远端、胫骨近端和腓骨手术钻孔的黄金标准。如果成功，这些 发展和研究将形成一个新的和令人兴奋的治疗肢体长度差异的基础， 孩子

PROJECT ABSTRACT This project addresses a need for less morbid alternatives to surgical drilling of growth plates in the treatment of limb length discrepancies. Surgical approaches currently require 6 weeks of recovery before weight bearing, which takes a physical and psychological toll on pediatric patients. Surgery has also been associated with complications such as incomplete growth arrest, angular deformity, bleeding, and infection. We hypothesize that microwave ablation – a technology already used for treating malignant and benign tumors throughout the body, including in bones – can be used to disrupt the growth plate with fewer complications and faster return to baseline activity. Preliminary data demonstrates the feasibility delivering microwave energy to create heating in the growth plate when using clinical microwave tumor ablation systems in porcine tibias. This project will focus on developing more optimal devices and techniques for growth plate ablation. Directional antennas will be developed that target microwave energy to the growth plate while minimizing collateral damage. Dynamic positioning and multi-applicator techniques will be used to further refine energy delivery to ensure complete and uniform growth arrest. Finally, the safety and efficacy of the optimized techniques will be compared against the gold-standard of surgical drilling in distal femur, proximal tibia, and fibula. If successful, these developments and studies will form the basis for a novel and exciting treatment for limb length discrepancy in children.