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Optimizing microwave ablation techniques for targeted cancer therapy

优化微波消融技术以进行癌症靶向治疗

基本信息

批准号：
8596258
负责人：
Christopher L Brace
金额：
$ 1.54万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-02-01 至 2014-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8596258
关键词：
Ablation Adoption Affect Algorithms Area Blood flow Body part Cancerous Clinic Clinical Clinical Trials Cryosurgery Data Development Devices Electric Conductivity Engineering Equipment Frequencies Growth Heating Histocompatibility Testing Human Hybrids Image Knowledge Lasers Liver Lung Medical Medicine Modality Modeling Monitor Operative Surgical Procedures Patient Care Patients Performance Phase Physiologic pulse Plague Preclinical Testing Procedures Property Puncture procedure Radiofrequency Interstitial Ablation Recurrence Reporting Role Source Specificity Speed System Techniques Technology Thermal Ablation Therapy Time Tissue Model Tissues Translations Treatment Efficacy Treatment Protocols base bone cancer care cancer therapy clinical efficacy clinical practice clinically relevant cryogenics design experience improved industry partner innovation interstitial killings microwave ablation microwave electromagnetic radiation minimally invasive oncology patient population public health relevance radiofrequency simulation stem therapy design tool tumor

项目摘要

DESCRIPTION (provided by applicant): The long-term objective of this project is to improve devices and techniques for microwave tumor ablation and extend its application into new patient populations by optimizing system design and energy delivery in several tissue types. Microwave ablation is superior to currently available technologies in many respects: microwaves provide rapid volumetric heating, leading to more precise and complete treatments; microwave heating is less dependent on tissue properties, making it more suitable for emerging targets (e.g., lung and bone); and using multiple antennas improves treatment control, precision and efficacy. Unfortunately, current systems have failed to deliver on these promises and patients who could benefit from improved therapies have suffered. This proposal is based on the idea that understanding more about microwave tissue heating will facilitate development of optimized systems and techniques that will enhance patient benefit and expand the role of microwave ablation in cancer care. As microwave ablation systems begin to enter the marketplace, optimized treatment protocols will be required to enhance patient benefit and expand the role of microwave ablation in clinical cancer care. To this end, we propose to: 1) Create improved numerical models of tissue to more accurately predict device performance. Hypothesis: Accurate tissue models improve numerical simulations, easing design and treatment optimization. 2) Optimize antenna designs and power delivery for tissue-specific treatments Hypotheses: Antenna design and frequencies can be optimized for specific tissues or treatment targets. Applying high-power pulses will more rapidly coagulate tissue microvasculature to improve efficacy. When combined, these optimizations will create ablations 50% faster and 25% larger than current systems. 3) Develop multiple-antenna application techniques to optimize treatment speed and specificity. Hypotheses: Multiple-antenna techniques improve efficacy and precision, allowing more tailored treatments without increasing invasiveness. Ablations can be created by 50% faster and 40% larger than current systems. 4) Facilitate real-time adaptive power control by using integrated treatment monitoring Hypothesis: Treatment monitoring can be accomplished without imaging, using only the interstitial applicator. If successful, this project will advance knowledge of microwave tissue heating, and create innovative and unique approaches to power delivery that utilize all of the advantages that microwaves offer. These aims will substantially change clinical practice by increasing the size of tumors that can be treated with microwaves, further broadening the scope of microwave ablation to areas outside the liver and increasing the number of patients benefiting from minimally invasive treatments.

描述（由申请人提供）：