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Structures and Activities of Prions and Prion Proteins

Structures and Activities of Prions and Prion Proteins
朊病毒和朊病毒蛋白的结构和活性
批准号：
8336077
负责人：
BYRON CAUGHEY
金额：
$72.15万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8336077
关键词：
Bovine Spongiform EncephalopathyChronic Wasting DiseaseCreutzfeldt-Jakob SyndromeDeuteriumDiseaseGoalsHydrogenMolecularMolecular ConformationMusNMR SpectroscopyNeurodegenerative DisordersPathogenesisPrion DiseasesPrionsRecombinantsRelative (related person)ScrapieSpectrum AnalysisStructurebeta pleated sheetdisease transmissionglycosylationinfrared spectroscopyprion seedssolid state nuclear magnetic resonancetransmission process

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中文摘要
翻译
1)我们利用红外光谱和固态核磁共振光谱研究了朊病毒种子重组PrP原纤维的结构，并在部分原纤维中发现了平行登记的β片构象的证据。2)结合红外光谱和氢氘交换光谱，我们区分了小鼠痒病朊病毒蛋白的菌株依赖构象，并确定糖基化和gpi锚定对构象的影响相对于菌株之间的构象差异是温和的。
英文摘要
Accomplishments for FY2011: 1) We have studied the structures of prion seeded recombinant PrP fibrils by infrared spectroscopy and solid-state nuclear magnetic resonance spectroscopy and found evidence for parallel-inregister beta sheet conformations in portions of those fibrils. 2) Using a combination of infrared and hydrogen-deuterium exchanges spectroscopies we have discriminated strain-dependent conformations of mouse scrapie prion protein and determined that the effects of glycosylation and GPI-anchoring on the conformations are modest relative to the conformational differences between strains.
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会议论文
Prion Disease Therapeutics
Structures and Activities of Prions and Prion Proteins
Prion Disease Therapeutics
Detection of Prions
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