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Prion Disease Therapeutics

Prion Disease Therapeutics
朊病毒病治疗
批准号:
10692133
负责人:
BYRON CAUGHEY
金额:
$1.73万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至

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中文摘要
翻译
我们为蛋白质病开发疗法的直接努力在本财年被搁置,因为我们专注于确定第一个高分辨率的病理性蛋白结构(见其他项目)。这样的结构开始为Pron的传播和毒性的分子机制提供关键的见解,在做的时候,建议新的治疗和药物筛选strategies.........................................................................................................................
英文摘要
Our direct efforts to develop therapeutics for proteopathies have been on hold this fiscal year as we have focussed on determining the first high-resolution structures of pathological prions (see other project). Such structures are beginning to provide key insights into the molecular mechanisms of prion propagation and toxicity, and, in doing, suggest new therapeutic and drug screening strategies.........................................................................................................................
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会议论文
Prion Disease Therapeutics
Structures and Activities of Prions and Prion Proteins
Prion Disease Therapeutics
Detection of Prions
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