The treatment of childhood obesity

描述（由申请人提供）：这是一项独立科学家奖（KO2）的提案，旨在扩大申请人关于青少年肥胖症行为干预的研究计划，以预防心血管风险因素和疾病。肥胖症治疗和维持体重减轻的有限进展主张专注于改善当前的治疗方法，并将基础行为科学转化为临床研究。本申请的目的是通过寻求专业合作和高级培训，开发一种多层次的方法来研究青少年肥胖症的行为治疗。本申请中概述的三个职业目标是1）获得进一步的知识和经验，为青少年肥胖治疗领域做出实质性贡献，2）努力优化目前可用的儿童肥胖治疗方法，并为临床创造这些治疗的可翻译版本，以及3）确定治疗超重和肥胖儿童的高度新颖的靶点，基于基础行为科学和神经科学的发现。职业发展活动包括与基础行为科学和神经科学工作的同事进行咨询，正式课程工作，实践培训以及与神经成像专家合作。支持这项申请将使PI有急需的时间专注于研究，并建立基础行为科学知识和神经生物学对肥胖和暴饮暴食的理解。Boutelle博士将获得知识，进行富有成效的转化研究，以改善和开发肥胖干预措施，并最大限度地发挥她对该领域的贡献。 公共卫生相关性：本申请的目的是支持受保护的研究时间，让Boutelle博士获得进一步的知识和经验，使她能够为儿童肥胖治疗领域做出重大贡献。

DESCRIPTION (provided by applicant): This is a proposal for an Independent Scientist Award (KO2) to expand the applicant's research program on behavioral interventions for obesity in youth, to prevent cardiovascular risk factors and disease Limited progress in obesity treatment and maintenance of weight loss argues for a focus on improving current treatments and for translating basic behavioral science to clinical research. The aim of this application is t develop a multilevel approach for studying behavioral treatments for obesity in youth by pursuing specialized collaborations and advanced training. The three career goals outlined in this application are 1) To gain further knowledge and experiences to substantially contribute to the field of the treatment of obesity in youth, 2) To work toward optimizing currently available approaches for child obesity treatment, and to create translatable versions of these treatments for the clinic and 3) To identify highly novel targets for the treatment of children who are overweight and obese, based on findings from basic behavioral sciences and on neuroscience. Career development activities include consultations with colleagues working in basic behavioral sciences and neuroscience, and formal course work, hands-on training, and collaboration with experts in neuroimaging. Support of this application will allow the PI the much needed time to focus on research and develop a base of basic behavioral sciences knowledge and neurobiological understanding of obesity and overeating. This application will allow Dr. Boutelle to gain the knowledge to conduct productive translational research to improve and develop obesity interventions, and maximize her contributions to the field. PUBLIC HEALTH RELEVANCE: The purpose of this application is to support protected research time for Dr. Boutelle to gain further knowledge and experiences that will allow her to significantly contribute to the field of child obesity treatment.