2012 Gordon Conference on Molecular Mechanisms in Lymphatic Function and Disease

2012 年戈登淋巴功能与疾病分子机制会议

• 批准号: 8302116
• 负责人: GUILLERMO C OLIVER
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-02 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8302116
• 关键词: Address; Animal Model; Area; Autoimmunity; Basic Science; Biochemistry; Biological Models; Biology; Biomedical Engineering; California; Cardiovascular Diseases; Cardiovascular system; Chronic; Clinical; Clinical Treatment; Data; Development; Disease; Doctor of Philosophy; Environment; Experimental Models; Faculty; Fostering; Functional disorder; Future; Generations; Genetic; Goals; Growth; Health; Homeostasis; Hospitals; Hypertension; Image; Immunologic Surveillance; Immunology; Inflammation; International; Investigation; Lead; Lipids; Liquid substance; Lymphangiogenesis; Lymphatic; Lymphatic vessel; Lymphedema; Malignant Neoplasms; Medicine; Minority; Molecular; Molecular and Cellular Biology; Nature; Obesity; Operative Surgical Procedures; Oral; Participant; Pathologic; Pathology; Pharmacology; Physicians; Physiology; Postdoctoral Fellow; PubMed; Publishing; Regulation; Research; Research Institute; Research Personnel; Role; Scientist; Sodium Chloride; Students; Translational Research; Translations; Tumor Biology; Vascular System; Woman; Work; absorption; abstracting; anticancer research; base; cardiovascular neoplasm; experience; graduate student; improved; in vivo; insight; interest; lipid metabolism; meetings; neglect; next generation; novel therapeutics; posters; success; symposium

DESCRIPTION (provided by applicant): This application is for partial support of the fifth Gordon Research Conference on Molecular Mechanisms in Lymphatic Function and Disease to be held in Ventura Beach Marriott in Ventura, California, between March 4-9, 2012. This conference has been held every two years since 2002 and is organized by the Gordon Research Conferences, an organization internationally known for the high quality, cutting edge nature of its meetings. Although a comparatively young GRC conference, attendance at the meeting has grown steadily since its inception over ten years ago. While historically neglected, research in the topics of lymphatic biology have experienced a dramatic growth within the last 10 years, in large part because the identification of critical regulators of lymphatic growth and the generation of valuable animal models. Until recently, the functional role of the lymphatic vascular system has been exclusively associated with lipid absorption, fluid homeostasis, and immune surveillance and lymphatic vessel dysfunction had been associated with symptomatic pathologic conditions such as lymphedema. Work in the last few years had led to a better understanding of the functional roles of this vascular system in health and disease. Furthermore, recent work has also unraveled additional functional roles of the lymphatic vasculature in fat metabolism, obesity, inflammation, and the regulation of salt storage in hypertension. Therefore, there is an unprecedented need for lymphatic biologists, cancer researchers, physiologists, biomedical engineers and physicians to have a forum in which to conduct a broad dialogue surrounding scientific developments in this field and to determine the direction of future basic and clinically- oriented investigative efforts. Lines of investigation tht have experienced a recent upsurge in next generation lymphatic investigation include, but are not limited to genetics, biochemistry and physiology, cellular and molecular biology, immunology, cancer research, cardiovascular medicine, bioengineering, in vivo imaging and pharmacology. As an example, there are 1517 postings on lymphangiogenesis on PubMed, with a third of those published in the last couple of years. This has lead to new insights into diseases such as cancer, cardiovascular diseases, chronic inflammation and lymphedema (both congenital and surgery-induced). The new lymphatic field finds applications in broad areas of pathology, inflammation, cardiovascular and tumor biology with new efforts for clinical translation. This meeting will bring together the leading basic and clinically oriented experts in the field of lymphatic biology and is expected to provide new insights into the mechanisms of disease and to promote the development of new therapeutic strategies.

描述(申请人提供)：本申请是为第五届戈登淋巴功能和疾病分子机制研究会议提供部分支持，会议将于2012年3月4日至9日在加利福尼亚州文图拉市的文图拉海滩万豪酒店举行。该会议自2002年以来每两年举行一次，由戈登研究会议组织，该组织以其会议的高质量和尖端性质而闻名国际。虽然GRC是一个相对年轻的会议，但自十多年前成立以来，出席人数一直在稳步增长。虽然在历史上被忽视，但在过去10年中，淋巴生物学主题的研究经历了戏剧性的增长，这在很大程度上是因为淋巴生长的关键调控因素的确定和有价值的动物模型的产生。直到最近，淋巴管系统的功能作用一直与脂质吸收、液体稳态和免疫监视有关，淋巴管功能障碍与淋巴水肿等症状性病理条件有关。过去几年的工作使人们更好地了解了这种血管系统在健康和疾病中的功能作用。此外，最近的工作还揭示了淋巴管系统在脂肪代谢、肥胖、炎症和高血压中盐储存调节中的额外功能作用。因此，淋巴生物学家、癌症研究人员、生理学家、生物医学工程师和医生需要有一个论坛，在这个论坛上围绕这一领域的科学发展进行广泛对话，并确定未来基础和临床研究工作的方向。最近在下一代淋巴研究方面经历了热潮的研究领域包括但不限于遗传学、生物化学和生理学、细胞和分子生物学、免疫学、癌症研究、心血管医学、生物工程、活体成像和药理学。例如，PubMed上有1517篇关于淋巴管生成的帖子，其中三分之一是在过去几年发表的。这带来了对疾病的新见解 例如癌症、心血管疾病、慢性炎症和淋巴水肿(先天性和外科手术引起的)。新的淋巴领域在病理学、炎症、心血管和肿瘤生物学的广泛领域得到了应用，并为临床翻译做出了新的努力。这次会议将汇集淋巴生物学领域领先的基础和临床专家，预计将为疾病机制提供新的见解，并促进新的治疗策略的发展。