2012 Gordon Conference on Molecular Mechanisms in Lymphatic Function and Disease

描述（由申请人提供）：本申请用于部分支持将于2012年3月4日至9日在加州文图拉的文图拉海滩万豪酒店举行的第五届淋巴功能和疾病分子机制戈登研究会议。自2002年以来，该会议每两年举行一次，由戈登研究会议组织，该组织以其会议的高质量，前沿性而闻名。虽然是一个相对年轻的GRC会议，但自十多年前成立以来，出席会议的人数稳步增长。 虽然历史上被忽视，但淋巴生物学主题的研究在过去10年中经历了戏剧性的增长，这在很大程度上是因为淋巴生长的关键调节因子的鉴定和有价值的动物模型的产生。直到最近，淋巴管系统的功能作用仅与脂质吸收、体液稳态和免疫监视相关，淋巴管功能障碍与有症状的病理状况如水肿相关。过去几年的工作使人们更好地了解了这种血管系统在健康和疾病中的功能作用。此外，最近的工作还揭示了淋巴管系统在脂肪代谢、肥胖、炎症和高血压中盐储存调节中的其他功能作用。因此，淋巴生物学家、癌症研究人员、生理学家、生物医学工程师和医生前所未有地需要有一个论坛，围绕该领域的科学发展进行广泛的对话，并确定未来基础和临床研究工作的方向。在下一代淋巴研究中经历了最近高潮的研究领域包括但不限于遗传学、生物化学和生理学、细胞和分子生物学、免疫学、癌症研究、心血管医学、生物工程、体内成像和药理学。例如，PubMed上有1517篇关于淋巴管生成的文章，其中三分之一是在过去几年发表的。这导致了对疾病的新见解 例如癌症、心血管疾病、慢性炎症和水肿（先天性和手术引起的）。新的淋巴领域在病理学，炎症，心血管和肿瘤生物学的广泛领域中找到了应用，并为临床翻译做出了新的努力。本次会议将汇集淋巴生物学领域领先的基础和临床专家，预计将为疾病机制提供新的见解，并促进新的治疗策略的发展。

DESCRIPTION (provided by applicant): This application is for partial support of the fifth Gordon Research Conference on Molecular Mechanisms in Lymphatic Function and Disease to be held in Ventura Beach Marriott in Ventura, California, between March 4-9, 2012. This conference has been held every two years since 2002 and is organized by the Gordon Research Conferences, an organization internationally known for the high quality, cutting edge nature of its meetings. Although a comparatively young GRC conference, attendance at the meeting has grown steadily since its inception over ten years ago. While historically neglected, research in the topics of lymphatic biology have experienced a dramatic growth within the last 10 years, in large part because the identification of critical regulators of lymphatic growth and the generation of valuable animal models. Until recently, the functional role of the lymphatic vascular system has been exclusively associated with lipid absorption, fluid homeostasis, and immune surveillance and lymphatic vessel dysfunction had been associated with symptomatic pathologic conditions such as lymphedema. Work in the last few years had led to a better understanding of the functional roles of this vascular system in health and disease. Furthermore, recent work has also unraveled additional functional roles of the lymphatic vasculature in fat metabolism, obesity, inflammation, and the regulation of salt storage in hypertension. Therefore, there is an unprecedented need for lymphatic biologists, cancer researchers, physiologists, biomedical engineers and physicians to have a forum in which to conduct a broad dialogue surrounding scientific developments in this field and to determine the direction of future basic and clinically- oriented investigative efforts. Lines of investigation tht have experienced a recent upsurge in next generation lymphatic investigation include, but are not limited to genetics, biochemistry and physiology, cellular and molecular biology, immunology, cancer research, cardiovascular medicine, bioengineering, in vivo imaging and pharmacology. As an example, there are 1517 postings on lymphangiogenesis on PubMed, with a third of those published in the last couple of years. This has lead to new insights into diseases such as cancer, cardiovascular diseases, chronic inflammation and lymphedema (both congenital and surgery-induced). The new lymphatic field finds applications in broad areas of pathology, inflammation, cardiovascular and tumor biology with new efforts for clinical translation. This meeting will bring together the leading basic and clinically oriented experts in the field of lymphatic biology and is expected to provide new insights into the mechanisms of disease and to promote the development of new therapeutic strategies.