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Functional roles of lymphatics in organogenesis and tissue repair

淋巴管在器官发生和组织修复中的功能作用

基本信息

批准号：
10326857
负责人：
GUILLERMO C OLIVER
金额：
$ 62.27万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-01-07 至 2024-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10326857
关键词：
Acute myocardial infarction Adult Animal Model Apoptosis Area Biology Blood Blood Vessels Cardiac Cardiac Edema Cardiac Myocytes Cardiac development Cells Cicatrix Communication Conditioned Culture Media Development Embryo Endothelial Cells Exhibits Foundations Genetic Transcription Goals Growth Growth Factor Heart Heart Abnormalities Heart Diseases Heart Injuries Homeostasis Human Injury Knockout Mice Knowledge Laboratories Lead Lymphangiogenesis Lymphatic Lymphatic Endothelial Cells Mammals Mass Spectrum Analysis Mediating Modeling Molecular Morphology Mus Myocardial Infarction Necrosis Nutrient Organ Organogenesis Oxygen PF4 Gene Paracrine Communication Pathologic Pathway interactions Play Prevention Process Production Regulation Reporting Research Resources Rodent Role Route Signal Transduction Therapeutic Tissues Vascular Endothelial Growth Factor C Western World Work Zebrafish base cardiac regeneration cardiac repair cardiogenesis cardioprotection diagnostic tool gain of function heart dimension/size heart function immune clearance improved induced pluripotent stem cell derived cardiomyocytes injured insight lymph flow lymphatic vasculature lymphatic vessel mortality mouse model mutant novel novel diagnostics novel therapeutics organ growth organ regeneration paracrine prevent protective factors regenerative therapeutic target tissue repair tool transcription factor transcriptome sequencing

项目摘要

SUMMARY Work performed during the last decade revealed the first molecular insights into lymphatic vascular biology. Some of those findings build the foundation for the studies to be pursued within this novel proposal. The goals are to take advantage of the expertise, tools and animal models my laboratory generated to investigate how lymphoangiocrine signals produced by cardiac associated lymphatic endothelial cells contribute to heart growth during development and cardiac repair after MI. This work should have an important impact in the way we think about traditional lymphatic functional roles, as well as in the way we treat cardiac disorders.

摘要在过去十年中进行的工作揭示了对淋巴管生物学的第一次分子洞察。其中一些发现为在这一新提议中进行的研究奠定了基础。目标是利用我的实验室产生的专业知识、工具和动物模型来研究心脏相关淋巴管内皮细胞产生的淋巴血管分泌信号有助于心脏生长在心肌梗死后的发育和心脏修复期间。这项工作应该会对我们的思维方式产生重要影响关于传统淋巴功能的作用，以及我们治疗心脏疾病的方式。