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Functional roles of lymphatics in organogenesis and tissue repair

Functional roles of lymphatics in organogenesis and tissue repair
淋巴管在器官发生和组织修复中的功能作用
批准号：
10326857
负责人：
GUILLERMO C OLIVER
金额：
$62.27万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
项目状态：
已结题
起止时间：
2021-01-07 至 2024-12-31
来源：
https://reporter.nih.gov/project-details/10326857
关键词：
Acute myocardial infarctionAdultAnimal ModelApoptosisAreaBiologyBloodBlood VesselsCardiacCardiac EdemaCardiac MyocytesCardiac developmentCellsCicatrixCommunicationConditioned Culture MediaDevelopmentEmbryoEndothelial CellsExhibitsFoundationsGenetic TranscriptionGoalsGrowthGrowth FactorHeartHeart AbnormalitiesHeart DiseasesHeart InjuriesHomeostasisHumanInjuryKnockout MiceKnowledgeLaboratoriesLeadLymphangiogenesisLymphaticLymphatic Endothelial CellsMammalsMass Spectrum AnalysisMediatingModelingMolecularMorphologyMusMyocardial InfarctionNecrosisNutrientOrganOrganogenesisOxygenPF4 GeneParacrine CommunicationPathologicPathway interactionsPlayPreventionProcessProductionRegulationReportingResearchResourcesRodentRoleRouteSignal TransductionTherapeuticTissuesVascular Endothelial Growth Factor CWestern WorldWorkZebrafishbasecardiac regenerationcardiac repaircardiogenesiscardioprotectiondiagnostic toolgain of functionheart dimension/sizeheart functionimmune clearanceimprovedinduced pluripotent stem cell derived cardiomyocytesinjuredinsightlymph flowlymphatic vasculaturelymphatic vesselmortalitymouse modelmutantnovelnovel diagnosticsnovel therapeuticsorgan growthorgan regenerationparacrinepreventprotective factorsregenerativetherapeutic targettissue repairtooltranscription factortranscriptome sequencing

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SUMMARY Work performed during the last decade revealed the first molecular insights into lymphatic vascular biology. Some of those findings build the foundation for the studies to be pursued within this novel proposal. The goals are to take advantage of the expertise, tools and animal models my laboratory generated to investigate how lymphoangiocrine signals produced by cardiac associated lymphatic endothelial cells contribute to heart growth during development and cardiac repair after MI. This work should have an important impact in the way we think about traditional lymphatic functional roles, as well as in the way we treat cardiac disorders.
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11th Latin American Society for Developmental Biology (LASDB) Conference
Mitochondrial respiration as a regulator of lymphatic cell fate and therapeutic lymphangiogenesis
Functional roles of lymphatics in organogenesis and tissue repair
Functional roles of lymphatics in organogenesis and tissue repair
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