Lymphatic Conference

项目摘要 本申请旨在请求对首届NAVBO-LE&RN淋巴会议的部分支持，该会议将 将于2017年6月8日至11日在伊利诺伊州芝加哥的西北医学院举行。淋巴生物学研究 在过去的10年里经历了戏剧性的增长。这可以从数量的增加中看出。 由于新一代研究人员的出现，以及通过增加 尽管研究其他主题，但纳入了与淋巴相关的问题的调查人员数量 为他们的利益着想。这一增长在一定程度上是由于淋巴生长的关键调节因素的确定和 动物模型的可用性，以及对淋巴管系统功能作用的更好理解 在健康和疾病方面。淋巴功能主要与脂肪吸收有关， 体液/大分子动态平衡、免疫监视和淋巴管功能障碍 与病理状况有关，如淋巴浮肿。然而，最近的工作发现了新的功能 淋巴管系统在新陈代谢、肥胖、炎症、盐储存调节中的作用 高血压、心脏病、青光眼，甚至可能是一些神经疾病。因此，有一个 极大地增加了对研究正常和病理淋巴组织的研究人员的需求 条件。随着该领域的发展和对淋巴对公共健康重要性的认识 对于疾病，需要更频繁的论坛，以交流相关主题的科学进展和想法 这可以将发育生物学家、癌症研究人员、生理学家、生物医学工程师聚集在一起， 心脏病学家、神经学家和内科医生。这些论坛将有助于促进目前在 淋巴相关疾病的识别和更好的特征。到目前为止，主要的淋巴研究 会议是GRC自2004年以来每两年举办一次的会议。虽然相对年轻， GRC会议自成立以来，出席人数稳步增长， 最后一次申请是在2016年，比允许的最大参与人数(200人)多了25人。 因此，显然有必要增加第二次两年一次的主要淋巴会议 这可以与现有的GRC交替使用。因此，这次首届淋巴会议将为 我们预计，这个系列在未来几年也将成为一种传统。就像在 提出的计划，选定的演讲者不仅涵盖了许多主要的研究课题，而且还将提出一个 特别强调淋巴研究的新功能领域，如新陈代谢、神经学 精神障碍、视力和心血管疾病。它还将把基础和临床科学家聚集在一起，我们将 用两次会议来讨论各种与淋巴相关的病理疾病。为了参加这次会议 更广泛，并促进与其他主题的研究人员的互动，整个会议将致力于新兴 在干细胞、表观遗传学和纳米技术等领域。

Project Summary This application is to request partial support of the inaugural NAVBO-LE&RN Lymphatic Conference that will take place at Northwestern Medical School in Chicago, Illinois on June 8-11, 2017. Research in lymphatic biology has experienced a dramatic growth within the last 10 years. This can be seen through the increase in the number of investigators, thanks to the emergence of a new generation of researchers, as well as through the increase in the number of investigators who, although working in other topics, have incorporated lymphatic-related questions into their interests. This growth is due, in part, to the identification of critical regulators of lymphatic growth and the availability of animal models, and to a better understanding of the functional roles of the lymphatic vasculature in health and disease. Lymphatic function has been primarily associated with lipid absorption, fluid/macromolecular homeostasis, and immune surveillance, and lymphatic vessel dysfunction has been associated with pathologic conditions such as lymphedema. However, recent work identified novel functional roles of the lymphatic vasculature in metabolism, obesity, inflammation, the regulation of salt storage in hypertension, heart disease, glaucoma and possibly even in some neurological disorders. Therefore, there is a dramatically increasing need for researchers working in a broad spectrum of normal and pathological lymphatic conditions. Along with the growth of the field and recognition of the public health importance of lymphatic diseases, there is a need for more frequent forums to exchange scientific progress and ideas in related topics that could bring together developmental biologists, cancer researchers, physiologists, biomedical engineers, cardiologists, neuroscientists and physicians. Such forums will help to promote the current progress in the identification and better characterization of lymphatic related disorders. Until now, the main lymphatic research conference was the one organized by the GRC every two years since 2004. Although a comparatively young GRC conference, attendance at the meeting has grown steadily since its inception and the number of applications for the last one in 2016, exceeded by 25 the maximum number of allowed participants (200). Accordingly, it has become apparent that there is a need to add a second major biennial lymphatic conference that can alternate with the established GRC. Therefore, this initial Lymphatic Conference will set the tone for those that will follow, as we expect that this series will also become a tradition in years to come. As seen in the proposed program, the selected speakers not only cover many of the major research topics, but will also put a special emphasis on the novel functional areas of lymphatic research, such as metabolism, neurological disorders, vision and cardiovascular diseases. It will also bring together basic and clinical scientists, as we will dedicate two sessions to discuss a variety of lymphatic-related pathological disorders. To make this conference broader and to foster interactions with researchers in other topics, an entire session will be devoted to emerging areas, such as stem cells, epigenetics and nanotechnology.