Preclinical Models Core (Core A)
临床前模型核心(核心 A)
基本信息
- 批准号:10460931
- 负责人:
- 金额:$ 26.62万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-08-01 至 2023-07-31
- 项目状态:已结题
- 来源:
- 关键词:Biological AssayBiological ModelsBiological ProductsCRISPR/Cas technologyCardiovascular PhysiologyCell LineCellsClone CellsCommunitiesConsultationsDatabasesDerivation procedureDevelopmentDiabetic NephropathyDiagnosisDiseaseDisease modelE-learningEducational workshopEmerging TechnologiesFocal Segmental GlomerulosclerosisGene TargetingGenerationsGenesGeneticHousingHumanHypertensionInjectionsInnovative TherapyInternationalKidneyKidney DiseasesKidney TransplantationLeadLeadershipMetabolismMethodologyMethodsMineralsModelingMolecularMonitorMouse StrainsMusNamesPathogenesisPathway interactionsPatientsPhenotypePhysiologyPolycystic Kidney DiseasesPostdoctoral FellowPre-Clinical ModelPreventionRenal functionResearchResearch PersonnelResearch SupportResourcesRodentRodent ModelRoleSamplingService delivery modelServicesStudentsSystemTalentsTechnical ExpertiseTestingTherapeuticTissue SampleTrainingTraining ProgramsTraining and EducationTransgenic MiceTranslatingTranslationsValidationVertebratesbasebiobankblastocystbonecandidate validationclinical translationcostdesigndisease phenotypeembryonic stem cellexperiencegene functiongenome editinghuman modelhuman tissuehumanized mousehypertensiveinduced pluripotent stem cellinduced pluripotent stem cell technologyinnovationinsightmeetingsmouse geneticsmouse modelnew technologynon-geneticnovel therapeuticsoutreachpre-clinicalprogramsranpirnaserepositorysynergismtherapeutic candidatetherapeutic developmenttherapeutic evaluationtherapeutic targettooltransplant modelweb portalwebinar
项目摘要
PROJECT SUMMARY – PRECLINICAL MODELS CORE
The Preclinical Models Core (PMC) will provide access to state-of-the art tools and services, education and
training programs and develop new methodologies focused on the discovery and early validation of therapeutic
targets for kidney diseases. Despite recent breakthroughs that have led to major advances in our
understanding of the pathogenesis of kidney diseases such as polycystic kidney disease and focal segmental
glomerulosclerosis, new therapies to diagnose, manage and cure these disorders have been slow to emerge.
A key step in the path to provide new treatments for kidney patients is the availability of sophisticated
preclinical model systems for basic discovery research, interrogation of newly identified pathways and early
target validation. In the PMC, we will exploit the extensive experience and technical expertise of our talented
kidney investigators while leveraging substantial Northwestern resources and bring them together under one
administrative umbrella to establish and provide easy access to: 1) NUmousekidney housing over 50 unique
genetic kidney disease mouse strains 2) a genome editing `concierge' service to rapidly design and generate
new genetic renal models 3) non-genetic kidney disease models including hypertensive and renal
transplantation models and state-of-the art mouse phenotyping services and 4) service for the generation and
genomic editing of induced pluripotent stem cells (iPSC) from patients with kidney diseases and an iPSCkidney
biobank. The PMC Core will also provide hands-on workshops and web-based training in mouse genetics,
genome editing, induced pluripotent stem cell (iPSC) technologies and phenotyping to kidney investigators and
trainees. Outreach and access to all Core-related services will be provided to the global kidney community
through an online web portal named nephro-HUB. Seamless integration and strong synergy with the
Therapeutics Development and Clinical Translation NU-GoKIDNEY Cores, the Pilot and Feasibility and
Enrichment Programs and an innovative Kidney Cure Accelerator program will catalyse discoveries and
accelerate their translation into innovative therapies for kidney patients.
项目摘要——临床前模型核心
临床前模型核心 (PMC) 将提供最先进的工具和服务、教育和
培训计划并开发新方法,重点关注治疗方法的发现和早期验证
肾脏疾病的目标。尽管最近取得的突破使我们的技术取得了重大进展
了解多囊肾、局灶节段性肾病等肾脏疾病的发病机制
肾小球硬化症的诊断、管理和治愈这些疾病的新疗法的出现进展缓慢。
为肾病患者提供新疗法的关键一步是获得先进的技术
用于基础发现研究、新发现的途径和早期研究的临床前模型系统
目标验证。在 PMC,我们将利用我们才华横溢的人员的丰富经验和技术专长
肾脏研究人员,同时利用西北大学的大量资源,并将他们聚集在一个
建立并提供便捷访问的行政保护伞:1) NUmousekidney 住房超过 50 个独特的
遗传性肾病小鼠品系 2) 基因组编辑“礼宾”服务,可快速设计和生成
新型遗传性肾病模型 3)非遗传性肾病模型,包括高血压、肾病等
移植模型和最先进的小鼠表型分析服务以及 4) 生成和移植服务
对来自肾病患者和 iPSC 肾脏的诱导多能干细胞 (iPSC) 进行基因组编辑
生物样本库。 PMC 核心还将提供小鼠遗传学方面的实践研讨会和基于网络的培训,
为肾脏研究人员提供基因组编辑、诱导多能干细胞 (iPSC) 技术和表型分析
实习生。将向全球肾脏界提供所有核心相关服务的外展和获取服务
通过名为 nephro-HUB 的在线门户网站。与企业无缝对接,形成强大协同效应
治疗开发和临床转化 NU-GoKIDNEY 核心、试点和可行性
浓缩计划和创新的肾脏治疗加速器计划将促进发现和
加速将其转化为肾脏患者的创新疗法。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('GUILLERMO C OLIVER', 18)}}的其他基金
11th Latin American Society for Developmental Biology (LASDB) Conference
第 11 届拉丁美洲发育生物学会 (LASDB) 会议
- 批准号:
10827693 - 财政年份:2023
- 资助金额:
$ 26.62万 - 项目类别:
Mitochondrial respiration as a regulator of lymphatic cell fate and therapeutic lymphangiogenesis
线粒体呼吸作为淋巴细胞命运和治疗性淋巴管生成的调节剂
- 批准号:
10640152 - 财政年份:2022
- 资助金额:
$ 26.62万 - 项目类别:
Functional roles of lymphatics in organogenesis and tissue repair
淋巴管在器官发生和组织修复中的功能作用
- 批准号:
10326857 - 财政年份:2021
- 资助金额:
$ 26.62万 - 项目类别:
Functional roles of lymphatics in organogenesis and tissue repair
淋巴管在器官发生和组织修复中的功能作用
- 批准号:
10117366 - 财政年份:2021
- 资助金额:
$ 26.62万 - 项目类别:
Functional roles of lymphatics in organogenesis and tissue repair
淋巴管在器官发生和组织修复中的功能作用
- 批准号:
10543140 - 财政年份:2021
- 资助金额:
$ 26.62万 - 项目类别:
2012 Gordon Conference on Molecular Mechanisms in Lymphatic Function and Disease
2012 年戈登淋巴功能与疾病分子机制会议
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8302116 - 财政年份:2012
- 资助金额:
$ 26.62万 - 项目类别:
THE ROLE OF THE HOMEOBOX SIX3 IN HOLOPROSENCEPHALY/CYCLOPIA
同源框 SIX3 在前脑无裂畸形/独眼畸形中的作用
- 批准号:
7387386 - 财政年份:2006
- 资助金额:
$ 26.62万 - 项目类别:
THE ROLE OF THE HOMEOBOX SIX3 IN HOLOPROSENCEPHALY/CYCLOPIA
同源框 SIX3 在前脑无裂畸形/独眼畸形中的作用
- 批准号:
7094949 - 财政年份:2006
- 资助金额:
$ 26.62万 - 项目类别:
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