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Use of Bacteriophages to Prevent, Diagnose, and Treat Diseases

Use of Bacteriophages to Prevent, Diagnose, and Treat Diseases
使用噬菌体预防、诊断和治疗疾病
批准号：
8348945
负责人：
SANKAR ADHYA
金额：
$37.52万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8348945
关键词：
Bacteriophage lambdaBacteriophagesCapsid ProteinsDiagnosisDiseaseDrug Delivery SystemsEngineeringHIVHIV InfectionsLaboratoriesMolecular BiologyOrganismPreventionProcessScreening procedureSystemVirionbasecancer celldevelopmental geneticsinfectious disease treatmentpreventtoolyeast two hybrid system

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中文摘要
翻译
摘要：利用2lambda系统识别药物靶标：发育遗传学继续努力，利用我们以前开发的基于2lambda的噬菌体两种杂交系统来识别HIV感染的靶标。我们克隆了HIV病毒粒子的5个主要外壳蛋白，鉴定了3对相互作用的伙伴蛋白。我们正在建立一个高通量的筛选程序，以识别小的非分子，这些非分子可以阻止病毒粒子中的这种相互作用，从而阻止HIV组装。
英文摘要
Summary: Use of 2 lambda system to identify drug target: The Developmental Genetics Section have continued our efforts to identify targets of HIV infection using our previously developed phage based 2lambda two hybrid systems. We have cloned 5 major coat proteins of HIV virion and identified 3 pairs of interacting partners. We are in the process of setting up a high through-put screening procedure to identify small non-molecules which prevent such interactions in the virion and thus HIV assembly.
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会议论文
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