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Use of Bacteriophages to Prevent, Diagnose, and Treat Diseases

Use of Bacteriophages to Prevent, Diagnose, and Treat Diseases
使用噬菌体预防、诊断和治疗疾病
批准号:
8157244
负责人:
SANKAR ADHYA
金额:
$41.25万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:

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中文摘要
翻译
总结:使用2 λ系统鉴定药物靶点:发育遗传学部分继续努力使用我们先前开发的基于噬菌体的2 λ双杂交系统鉴定HIV感染的靶点。我们克隆了HIV病毒体的5个主要外壳蛋白,并鉴定了3对相互作用的配偶体。我们正在建立一个高通量的筛选程序,以确定小的非分子,防止这种相互作用的病毒粒子,从而艾滋病毒的装配。
英文摘要
Summary: Use of 2 lambda system to identify drug target: The Developmental Genetics Section have continued our efforts to identify targets of HIV infection using our previously developed phage based 2lambda two hybrid systems. We have cloned 5 major coat proteins of HIV virion and identified 3 pairs of interacting partners. We are in the process of setting up a high through-put screening procedure to identify small non-molecules which prevent such interactions in the virion and thus HIV assembly.
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Bacteriophage in Prevention, Diagnosis and Treatment
The Use of Bacteriophage in the Prevention, Diagnosis, and Treatment of Human Di
Bacteriophage in the Prevention/Diagnosis/Treatment
Regulation of Gene Transcription
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