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testing the effect of a DPP-4 inhibitor on immune function

testing the effect of a DPP-4 inhibitor on immune function
测试 DPP-4 抑制剂对免疫功能的影响
批准号：
8553620
负责人：
Kristin Tarbell
金额：
$41.82万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8553620
关键词：
AftercareAutoimmune DiabetesAutoimmune ProcessAutoimmunityBeta CellBiological AssayBlood GlucoseBlood specimenCell physiologyCleaved cellClinical ProtocolsClinical TrialsDataDiabetes MellitusDipeptidyl-Peptidase IVDiseaseDouble-Blind MethodEnzymesFlow CytometryGene ExpressionHalf-LifeHyperglycemiaImmuneImmune responseImmune systemIndividualInfectionInflammationInsulinInsulin-Dependent Diabetes MellitusLeukocyte TraffickingLeukocytesLymphocyte SubsetMeasuresMinorMusNon-Insulin-Dependent Diabetes MellitusPancreasPatientsPlacebosPlasmaProductionProteinsRandomizedRegulatory T-LymphocyteSamplingStructure of beta Cell of isletTestingToxic effectTransforming Growth Factor betaWhole Bloodchemokinecytokineglucagon-like peptidehealthy volunteerhuman TGFB1 proteinimmune functionimprovedimproved functioninginhibitor/antagonistinsulin dependent diabetes mellitus onsetkillingsprimary outcometime interval

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中文摘要
翻译
在过去的一年里，我们已经完成了对临床方案样本的计划分析，评估dpp -4特异性抑制剂（西格列汀/Januvia）对健康个体免疫功能的影响。结果分析正在进行中。目前的分析表明，西格列汀并没有显著改变我们测量的大多数免疫读数，包括血浆tgf - β和其他细胞因子的水平，以及pmcs的流式细胞术。收集的流式细胞术数据包括Treg分析和CD26在淋巴细胞亚群上的表达。
英文摘要
In the past year, we have completed planned assays on samples from the clinical protocol, Assessment of the Effects of A DPP-4-Specific Inhibitor (Sitagliptin/Januvia) on Immune Function in Healthy Individuals. Analysis of results is ongoing. Current analysis indicates that sitagliptin does not significantly alter most of the immune readouts we measured, including levels of plasma TGF-beta and other cytokines, and flow cytometry on PBMCs. Flow cytometry data collected include Treg analysis and expression of CD26 on lymphocyte subsets.
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dendrtitic cell subsets in autoimmune diabetes
Dendritic cell subsets in autoimmune diabetes
testing the effect of a DPP-4 inhibitor on immune function
Dendritic cell subsets in autoimmune diabetes
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