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Structural determinants and mechanisms underlying the Major Histocompatibility Complex Class II gene-linked resistance to autoimmune diabetes

Structural determinants and mechanisms underlying the Major Histocompatibility Complex Class II gene-linked resistance to autoimmune diabetes
主要组织相容性复合体 II 类基因相关的自身免疫性糖尿病抵抗的结构决定因素和机制
批准号:
461072
负责人:
Santamaria Pere
金额:
$77.47万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2022
资助国家:
加拿大
项目状态:
未结题
起止时间:
2022-03-01 至 2027-03-01

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中文摘要
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英文摘要
Type 1 diabetes (T1D) results from immune dysregulation (autoimmunity) leading to destruction of the insulin-producing cells of the pancreas (beta cells) by killer white blood cells. Susceptibility and resistance to T1D are both genetically determined, bu
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Epigenetic and transcriptional regulation of a novel T-follicular helper (TFH)-to-T-regulatory type-1 (TR1) cell differentiation pathway
  • 批准号:
    461070
  • 项目类别:
    Operating Grants
  • 资助金额:
    $76.91万
  • 财政年份:
    2022
  • 负责人:
    Santamaria Pere
  • 依托单位:
Mechanisms underlying the formation of autoantigen-specific regulatory networks in vivo
  • 批准号:
    342027
  • 项目类别:
    Operating Grants
  • 资助金额:
    $78.25万
  • 财政年份:
    2016
  • 负责人:
    Santamaria Pere
  • 依托单位:
Advancing antigen-specific nanomedicines for the treatment of autoimmune disease: mechanistic and translational studies.
  • 批准号:
    332902
  • 项目类别:
    Operating Grants
  • 资助金额:
    $249.45万
  • 财政年份:
    2015
  • 负责人:
    Santamaria Pere
  • 依托单位:
T-cell tolerance versus the genetic resistance to spontaneous autoimmune diabetes in mice.
  • 批准号:
    304696
  • 项目类别:
    Operating Grants
  • 资助金额:
    $73.97万
  • 财政年份:
    2014
  • 负责人:
    Santamaria Pere
  • 依托单位:
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