课题基金 / 基金详情

testing the effect of a DPP-4 inhibitor on immune function

testing the effect of a DPP-4 inhibitor on immune function
测试 DPP-4 抑制剂对免疫功能的影响
批准号：
8741575
负责人：
Kristin Tarbell
金额：
$29.72万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8741575
关键词：
AftercareAutoimmune DiabetesAutoimmune ProcessAutoimmunityBeta CellBlood GlucoseBlood specimenCell physiologyCleaved cellClinical ProtocolsClinical TrialsDataDiabetes MellitusDipeptidyl-Peptidase IVDiseaseDouble-Blind MethodEnzymesFlow CytometryGene ExpressionHalf-LifeHyperglycemiaImmuneImmune responseImmune systemIndividualInfectionInflammationInsulinInsulin-Dependent Diabetes MellitusLeukocyte TraffickingLeukocytesLymphocyte SubsetMeasuresMinorMusNon-Insulin-Dependent Diabetes MellitusPancreasPatientsPlacebosPlasmaProductionProteinsPublicationsRandomizedRegulatory T-LymphocyteStructure of beta Cell of isletTestingToxic effectTransforming Growth Factor betaWhole Bloodchemokineclinically relevantcytokineglucagon-like peptidehealthy volunteerhuman TGFB1 proteinimmune functionimprovedimproved functioninginhibitor/antagonistinsulin dependent diabetes mellitus onsetkillingsprimary outcometime interval

项目摘要

项目成果

Kristin Tarbell的其他基金

相似基金

相关文献

中文摘要
翻译
在过去的一年里，我们已经完成了临床方案的计划分析结果，评估dpp -4特异性抑制剂（西格列汀/Januvia）对健康个体免疫功能的影响。我们的分析表明西格列汀并没有显著改变我们测量的大多数免疫读数，包括血浆tgf - β和其他细胞因子的水平，以及PBMCs的流式细胞术。收集的流式细胞术数据包括Treg分析和CD26在淋巴细胞亚群上的表达。我们确实观察到西格列汀治疗后早期CD26表达的微小但显著的变化，但这些变化并没有持续，因此不太可能与临床相关。这项研究已被接受发表。
英文摘要
In the past year, we have completed planned analysis of results from the clinical protocol, Assessment of the Effects of A DPP-4-Specific Inhibitor (Sitagliptin/Januvia) on Immune Function in Healthy Individuals. Our analysis has indicated that sitagliptin does not significantly alter most of the immune readouts we measured, including levels of plasma TGF-beta and other cytokines, and flow cytometry on PBMCs. Flow cytometry data collected include Treg analysis and expression of CD26 on lymphocyte subsets. We did observe small but significant changes in CD26 expression early after sitagliptin treatment, but these changes were not sustained, and therefore are not likely to be clinically relevant. This study has been accepted for publication.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
testing the effect of a DPP-4 inhibitor on immune function
dendrtitic cell subsets in autoimmune diabetes
Dendritic cell subsets in autoimmune diabetes
Dendritic cell subsets in autoimmune diabetes
海外基金