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testing the effect of a DPP-4 inhibitor on immune function

testing the effect of a DPP-4 inhibitor on immune function
测试 DPP-4 抑制剂对免疫功能的影响
批准号：
8349934
负责人：
Kristin Tarbell
金额：
$47.3万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8349934
关键词：
AftercareAutoimmune DiabetesAutoimmune ProcessAutoimmunityBeta CellBiological AssayBlood GlucoseBlood specimenCell physiologyCleaved cellClinical ProtocolsClinical TrialsDataData CollectionDiabetes MellitusDipeptidyl-Peptidase IVDiseaseDouble-Blind MethodEnzymesFlow CytometryGene ExpressionHalf-LifeHyperglycemiaImmuneImmune responseImmune systemIn VitroIndividualInfectionInflammationInsulinInsulin-Dependent Diabetes MellitusLeukocyte TraffickingLeukocytesLymphocyte SubsetMeasuresMinorMusNon-Insulin-Dependent Diabetes MellitusPancreasParticipantPatientsPlacebosPlasmaProductionProteinsRNARandomizedRegulatory T-LymphocyteStructure of beta Cell of isletT-Cell ActivationTestingToxic effectTransforming Growth Factor betaWhole Bloodchemokinecytokineglucagon-like peptidehealthy volunteerhuman TGFB1 proteinimmune functionimprovedimproved functioninginhibitor/antagonistinsulin dependent diabetes mellitus onsetkillingsprimary outcomeresearch studytime interval

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中文摘要
翻译
在过去的一年里，我们完成了临床方案“评估dpp -4特异性抑制剂（西格列汀/Januvia）对健康个体免疫功能的影响”的所有参与者的招募。研究分析正在进行中。我们的许多检测数据收集已经完成，包括血浆细胞因子、全血RNA微阵列、pbmc流式细胞术。收集的流式细胞术数据包括Treg分析和CD26在淋巴细胞亚群上的表达。剩余的免疫试验数据，包括体外刺激细胞因子水平和T细胞活化，将很快完成。
英文摘要
In the past year, we have completed recruitment of all participants for the clinical protocol, Assessment of the Effects of A DPP-4-Specific Inhibitor (Sitagliptin/Januvia) on Immune Function in Healthy Individuals. The research study assays are ongoing. Data collection is complete for many of our assays, including plasma cytokine, microarray on whole blood RNA, flow cytometry on PBMCs. Flow cytometry data collected include Treg analysis and expression of CD26 on lymphocyte subsets. Data for the remaining immune assays including in vitro-stimulated cytokine levels and T cell activation will be completed soon.
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