Technology Transfer

NIDCRS技术转让办公室处理了333份材料转让协议和保密协议。NIDCR将外发材料与来料的比例维持在大约5：1的水平。2011财年有5个新的许可证被执行，其中包括据我们所知的NIHS第一个将干细胞技术独家授权给私人公司的许可证。2011财年的特许权使用费总额预计将超过NIDCR技术转让办公室的分配预算。提交了9份员工发明报告，包括针对Sjgrens综合征、口干症和糖尿病的发明。一项值得注意的成就是成功地将树脂毒素(RTX)转让给一家私营公司，其中包括NIHS First，将孤儿药物指定与独家许可证相结合，签署了一份形成临床中心、NINDS和NIDCR之间的合作伙伴关系的协议书，以及NIDCRs与被许可方共同提供RTX NINDS CRADA的科学、临床和财务支持。办公室工作人员在技术转让预算内提醒管理层注意专利费用中的严重超额债务的努力产生了积极的影响：NIH技术转移办公室正在制定监测解除债务的指标，并正在与许可证和专利经理沟通，以确定减少不必要的超额债务的方法。由于大量使用技术转让服务，以及新实施的NIH和NIDCR材料转让政策加强了监督，增加了工作量，2011财年，技术转让办公室填补了一个全职技术开发专家职位。

NIDCRs technology transfer office processed 333 material transfer agreements and confidentiality agreements. NIDCR maintains an approximate 5:1 ratio of outgoing materials as compared to incoming materials. There were 5 new licenses executed in FY2011, includingto our knowledge--the NIHs first exclusive license of a stem cell technology to a private company. Total royalties for FY2011 are expected to exceed the allocated budget for the NIDCR technology transfer office. Nine Employee Invention Reports were filed, including inventions directed towards Sjgrens Syndrome, xerostomia, and diabetes. A notable achievement was the successful transfer of resiniferatoxin (RTX) to a private firm, which involved NIHs first, combined Orphan Drug Designation with exclusive license, execution of a Letter of Agreement forming a partnership between the Clinical Center, NINDS and NIDCR, and NIDCRs scientific, clinical, and financial support of a RTX NINDS CRADA with the licensee. Office staffs efforts to alert management of significant over-obligations in the patent expenses within the technology transfer budget has had positive ramifications: the NIH Office of Technology Transfer is developing metrics that monitor de-obligations and is communicating with License and Patent Managers to identify ways to reduce unnecessary over-obligations. Due to the increased workload due to heavy use of technology transfer services and improved oversight from newly implemented NIH and NIDCR material transfer policies, the technology transfer office filled a full-time Technology Development Specialist position in FY2011.