Animal Research Infrastructure Intramural Research Program

在上一个财政年度，NIDCR的校内动物研究项目使用了大约66500只小鼠和975只大鼠。该项目还使用了4只豚鼠进行不涉及疼痛或痛苦的研究。2011年6月，作为美国国立卫生研究院校内动物项目认证的一部分，国际实验动物护理评估和认证协会访问了NIDCR动物项目并对其进行了认证。下一次三年一次的实地考察预计将于2014年6月进行。该项目提供了一个专门为NIDCR研究人员提供的动物设施，可容纳5760个老鼠笼子，最多可容纳28800只老鼠。2011年8月，该动物设施的笼子入住率约为指定空间的95%。在贝塞斯达国立卫生研究院校园的其他共享或集中动物设施中提供额外的小鼠住房，可容纳3,040多个小鼠笼子，容量为15,200只小鼠。共用设施提供224个鼠笼，可容纳约650只老鼠。在上一个财政年度，NIDCR ACUC批准在校园内建立一个永久的卫星设施，该设施可容纳约36个老鼠笼子，可容纳180只老鼠和15个老鼠笼子，可容纳45只老鼠。目前，还有10只爪蟾被安置在NIH的另一个动物设施中。目前，NIDCR的校内项目没有使用非人类灵长类动物、狗、猫、农场动物或鱼类。NIDCR动物护理和使用委员会审查、批准或要求修改43项动物研究提案和33项提案修正案。所有动物使用者和主要研究者以及ACUC成员都需要进行培训。NIDCR ACUC成员定期参加国家会议和研讨会，接受关于实验动物护理和使用的法规遵从性的高级培训。NIDCR校内科学家创造并培育转基因小鼠，用于NIDCR运营和其他共享动物设施的实验使用。NIDCR动物项目正在不断分享这些宝贵的动物资源，并进口额外的转基因小鼠用于特定的研究。

In the last fiscal year the NIDCR intramural animal research program used about 66,500 mice and 975 rats. The program also used 4 guinea pigs in research not involving pain or distress. The NIDCR animal program was visited and accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International in June 2011 as part of the accreditation of the intramural animal program of the National Institutes of Health intramural program. The next triennial site visit is expected in June 2014. The program provides an animal facility dedicated to only NIDCR investigators that can accommodate 5,760 mouse cages with a capacity up to 28,800 mice. The cage occupancy rate of that animal facility was about 95% of assigned space in August 2011. Additional mouse housing is provided in other shared or centralized animal facilities on the Bethesda NIH campus that can accommodate 3,040 more mouse cages with a capacity of 15,200 mice. Housing for rats is available for 224 rat cages in a shared facility, with a capacity of about 650 rats. In the last fiscal year, the NIDCR ACUC approved the establishment of a permanent satellite facility on campus which accommodates approximately 36 mouse cages with a capacity of 180 mice and 15 rat cages with a capacity of 45 rats. Currently, there are also ten Xenopus frogs that are housed in another NIH animal facility. At this time no nonhuman primates, dogs, cats, farm animals, or fish are used by the intramural program of NIDCR. The NIDCR Animal Care and Use Committee reviewed and approved, or requested modifications for approval of 43 animal study proposals and 33 proposal amendments. Training is required for all animal users and principal investigators, and ACUC members. NIDCR ACUC members regularly attend national meetings and workshops for advanced training in regulatory compliance for laboratory animal care and use. NIDCR intramural scientists create and breed transgenic mice for experimental use in NIDCR operated and other shared animal facilities. The NIDCR animal program is continually sharing these valuable animal resources and importing additional transgenic mice for specific research studies.