Neuromedical Core (Page 348)

抗逆转录病毒疗法的进步降低了但没有消除死亡率和神经系统发病率 与HIV感染有关。这一流行病已转变为一种慢性病， 维持病毒持久性的机制与宿主免疫策略之间的动态平衡， 与抗逆转录病毒疗法相结合，控制病毒活性。根除或治愈的前景是 许多年或几十年后。展望未来，HNRC认为有四个一般领域， 研究需求最大。因此，在更新期间，神经医学核心（NMC）将开发 并完善其研究基础设施，以支持针对老龄化、急性和早期 HIV感染与临床相关性。连接这三个主题的一条共同线索是遗传学--两者都是宿主 和病毒。 新组织的NMC由两个包含公共资源的协作单元组成 （设备，用品）和工作人员进行日常互动：临床研究支持单位（CRSU）;和 a实验室、药理学和生物标志物股。这些单位将共同对所有 HIV+受试者和HIV-对照者，包括入组发育核心试验研究的受试者。的 神经医学核心（NMC）的总体目标是提供全面的临床和 实验室评估、科学咨询、指导、培训和社区教育， 神经艾滋病在目前的资助期间，NMC促进了70个研究项目，包括观测 队列研究、临床病理学研究、影像学研究、临床试验和国际研究 由加州大学圣地亚哥分校和许多其他机构的合作研究人员进行。 通过协助调查人员在项目开发的各个层面上广泛不同的学科， 概念化的假设，研究执行，分析，解释和传播， NMC鼓励应用多种科学观点，并促进跨学科 合作与协调。通过面对面会议等多种灵活机制 和视频电话会议，我们将密切合作，与神经影像，神经行为， 神经病毒学，神经生物学，发展和国际核心，以进一步HNRC的 跨学科的目标。

Advances in antiretroviral therapy have reduced but not eliminated mortality and neurologic morbidity related to HIV infection. The epidemic has been transformed into a chronic disease in which there is a dynamic equilibrium between mechanisms maintaining viral persistence and host immune strategies that, in combination with antiretroviral therapy, hold viral activity in check. Prospects for eradication or cure are many years or decades away. Looking toward the future, the HNRC perceives four general areas in which research needs are greatest. In the renewal period, the Neuromedical Core (NMC) will therefore develop and mature its research infrastructure to support studies addressing the themes of aging, acute and early HIV infection and clinical relevance. A common thread linking these three themes is genetics-both host and viral. The newly-organized NMC is made up of two cooperative units comprising common resources (equipment, supplies) and staff that interact on a daily basis: a Clinical Research Support Unit (CRSU); and a Laboratory, Pharmacology & Biomarker Unit (LPBU). Together these units will perform evaluations on all HIV+ subjects and HIV- controls, including those enrolled in pilot studies of the Developmental Core. The over-arching objectives of the Neuromedical Core (NMC) are to provide comprehensive clinical and laboratory evaluations, scientific consultation, and mentorship, training, and community education in NeuroAIDS. In the current funding period the NMC facilitated 70 research projects including observational cohort studies, clinical-pathological investigations, imaging studies, clinical trials and international research performed by collaborating investigators at UCSD and many other institutions. By assisting investigators in widely diverging disciplines at all levels of project development, from conceptualization of hypotheses to study implementation, analysis, interpretation and dissemination, the NMC encourages the application of multiple scientific perspectives and stimulates interdisciplinary collaboration and coordination. Through a variety of flexible mechanisms including face-to-face meetings and video teleconferences we will collaborate closely with the Neuroimaging, Neurobehavioral, Neurovirology, Neurobiology, Developmental and International Cores to further the HNRC's transdisciplinary aims.