ACTIVITY 2: BIOACTIVE NUTRIENTS CORE

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 生物活性营养素活动的总体目标是调查在人类疾病预防中可能有效的营养成分，这些营养成分是诊断后治疗中使用的更传统程序或疗法的高性价比、非侵入性替代方案。考虑到饮食干预可能带来的重大健康问题，以及夏威夷采取这一行动的可能性，我们的长期目标是在其他模型系统的初步研究基础上，使用多学科、转化的方法来理解人类基于营养的疾病预防背后的分子、细胞和组织机制。生物活性营养素活动促进了有前途的年轻研究人员的研究项目，一个是在小鼠模型中研究膳食补充剂硒对急性和慢性哮喘发展的影响，另一个是在动物模型中调查竹子(竹子)成分减少乳腺癌生长的有效性。显微镜和其他成像方法是广泛的生物医学研究工作中的关键技术。NCRR--以及UHM的其他外部支持项目--数量的迅速增加，导致了在协调和确定相互竞争的研究基础设施需求和科学目标的优先顺序方面面临更大的挑战。组织和成像核心设施(http://www2.jabsom.hawaii.edu/histocore/index.html)的总体目标是将各种显微镜和其他成像系统整合到一个单一的核心设施中，以最大限度地利用这些资源，汇集不同的专业知识和技术，并促进方法和试剂的合作和交流。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The overall goal of the Bioactive Nutrients activity is to investigate nutritional components that may have efficacy in human disease prevention and are highly cost-effective, non-invasive alternatives to the more conventional procedures or therapeutics utilized in post-diagnosis treatment. Given the significant health problems that are amenable to dietary intervention, and the potential for this course of action in Hawaii, our long-term goals are to use multidisciplinary, translational approaches to understand the molecular, cellular and organismal mechanisms behind nutrition-based disease prevention in humans, based on preliminary studies in other model systems. The Bioactive Nutrients activity fosters research projects by promising young investigators, one dealing with the effects of the dietary supplemental selenium on the development of acute and chronic asthma in a mouse model, and the other investigating the efficacy of components in bamboo (Phyllostachys edulis) to reduce breast cancer growth in an animal model. Microscopy and other imaging methods are critical techniques in a broad range of biomedical research endeavors. Rapid expansion in the number of NCRR- and other extramurally supported programs at UHM, has resulted in far greater challenges in the coordination and prioritization of competing research-infrastructure needs and scientific goals. The overall goal of the Histology and Imaging Core Facility (http://www2.jabsom.hawaii.edu/histocore/index.html) is to consolidate a variety of microscopes and other imaging systems into a single core facility to maximize use of these resources, bring together diverse expertise and technology, and foster collaboration and exchange of methodologies and reagents.