Integrative Center for Precision Nutrition and Human Health

项目总结 精准营养是精准医学的一个新的组成部分，它利用了 饮食成分被吸收、代谢并转化为能量，以及这些能量是如何被利用的， 导致饮食和营养需求大相径庭。在夏威夷，文化和习俗影响着饮食 偏好和经济差距影响食物的获取，进一步放大营养需求和 个体对饮食成分的反应。认识到通过以下途径提供的创新新机会 精确的营养方法，以及有效的营养健康益处的变革潜力， 特别是对于夏威夷的土著和未得到充分服务的人，夏威夷大学提议建立 一个多成分中心，支持以精准营养为主题的多学科研究。 这个生物医学研究卓越中心(COBRE)第一阶段计划的总体目标是创造 夏威夷大学马诺阿分校精密营养与人类健康综合中心 (Uhm)，因为它将包括精确营养研究和人类之间的接口 健康结果。我们的目标是为培养一支未来的领导人和 精准营养导师，他们的努力成果反哺对人类的积极影响 健康，并广泛传播和实施健康战略和干预措施，滋养 这款精密营养眼镜蛇的可持续性。打造精准营养眼镜蛇的总体目标 这将通过以下方式实现，以促进研究、职业发展和社区卫生方面的卓越 以下三个具体目标：目标1：创建精准营养与人类综合中心 健康建立在有影响力的、科学严谨的研究、教育和培训的基础上；建立在 有前途的未来科学领袖；并由杰出的个人精心制作、团队促进的指导培养出来 和职业发展活动。目标2：为研究人员提供切割方面的教育和培训 前沿技术和对最先进研究核心设施的访问，将这些资源与 UH的其他研究和培训计划和设施，夏威夷的基于社区的研究，以及 这个想法在全国范围内传播开来。目标3：促进发展强有力的协作关系 在学术研究人员和社区之间，基于文化敏感的方法，目标是 为所有人带来实实在在的健康益处。通过精准营养科布雷的共同努力 研究人员和我们的社区合作伙伴，在社区参与和外联的指导下 核心，我们将共同推进精准营养，分享和传播有益健康 在整个社区、国家和其他地方采取战略和干预措施并取得积极成果。这个 该中心的长期目标是通过精准营养的优势促进健康，实施 在整个社区和更远的地方，从而对人类健康产生持久、深远的积极影响。

PROJECT SUMMARY Precision nutrition is a new and now integral component of precision medicine that exploits differences in how dietary components are absorbed, metabolized and converted to energy, and in how that energy is utilized, resulting in widely varying dietary and nutrient requirements. In Hawaii, culture and customs influence dietary preferences and economic disparities affect food access, further amplifying differences in nutritional needs and individual responses to dietary components. Recognizing the innovative new opportunities available through precision nutrition approaches, and the transformative potential for impactful nutritional health benefits, particularly to the indigenous and underserved people of Hawaii, the University of Hawaii proposes to establish a multicomponent center that enables multidisciplinary research with the thematic focus of Precision Nutrition. The overall goal of this Centers of Biomedical Research Excellence (COBRE) Phase I proposal is the creation of an Integrative Center for Precision Nutrition and Human Health at the University of Hawai’i at Manoa (UHM), ‘integrative’ in that it will encompass the interface between precision nutrition research and human health outcomes. Our objectives are to build the foundation needed to grow a cadre of future leaders and mentors in precision nutrition, the fruits of their efforts feeding the attainment of positive impacts on human health, and to broadly disseminate and implement healthful strategies and interventions, nourishing the sustainability of this Precision Nutrition COBRE. The overall goal of creating a Precision Nutrition COBRE that fosters excellence in research, career development, and community health, will be achieved through the following three Specific Aims: Aim 1: To create an Integrative Center for Precision Nutrition and Human Health founded on impactful, scientifically rigorous research, education and training; built around a cadre of promising future scientific leaders; and fostered by outstanding individually-crafted, team-facilitated mentoring and career development activities. Aim 2: To provide research investigators education and training in cutting edge technologies and access to state-of-the-art research Core Facilities, integrating these resources with other research and training programs and facilities at UH, with community-based research in Hawaii, and with the IDeA network across the nation. Aim 3: To promote development of strong collaborative relationships between academic researchers and the community, based on culturally sensitive approaches, with the goal of achieving tangible health benefits for all. Through the combined efforts of Precision Nutrition COBRE researchers and our community partners, with the guidance of the Community Engagement and Outreach Core, we will collaboratively advance precision nutrition, share and disseminate beneficial and healthful strategies and interventions and positive outcomes throughout the community, the State and beyond. The long term goal of the Center is to promote health through the advantages of precision nutrition, implemented across the community and beyond, thereby producing lasting, far-reaching positive impacts on human health.