Withdrawal Exposure with Withdrawal Regulation Training for Smoking Cessation

戒断暴露和戒烟戒断训练

• 批准号: 8302223
• 负责人: Peter S. Hendricks
• 金额: $ 21.98万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-15 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8302223
• 关键词: Abstinence; Accounting; Address; Adult; Behavioral; Cessation of life; Characteristics; Cigarette; Cognitive; Data; Development; Drug usage; Educational Intervention; Expectancy; Goals; Hour; Intention; Intervention; Investigation; Knowledge; Manuals; Mediator of activation protein; Modification; Morbidity - disease rate; Motivation; Nicotine Withdrawal; Outcome; Participant; Pilot Projects; Play; Process; Public Health; Randomized; Regulation; Relapse; Relative (related person); Relaxation Therapy; Research; Research Design; Resistance; Role; Sample Size; Self Efficacy; Severities; Smoker; Smoking; Smoking Cessation Intervention; Smoking Status; Techniques; Testing; Therapeutic; Tobacco Dependence; Training; Treatment Protocols; Treatment outcome; United States; Withdrawal; Withdrawal Symptom; Withholding Treatment; addiction; base; cigarette smoking; in vivo; mortality; novel; smoking cessation; theories

DESCRIPTION (provided by applicant): Cigarette smoking remains the single most preventable cause of mortality and morbidity in the United States. Long-term abstinence rates for even the most rigorous of smoking cessation treatments range between 20 percent and 35 percent. It is therefore essential that research continue to investigate novel smoking cessation interventions. Considerable evidence suggests that withdrawal processes form the motivational basis for cigarette smoking and play a critical role in relapse to cigarette use. While withdrawal from nicotine, or pharmacologic withdrawal, may be limited to 10 days, withdrawal from the act of smoking, or behavioral withdrawal, may persist indefinitely. Accordingly, it has been suggested that smoking cessation interventions may be augmented by aiding smokers in the practice of withdrawal regulation strategies. The primary goal of this investigation is to pilot an in vivo early withdrawal exposure with withdrawal regulation training intervention for smoking cessation. Specific aims include: informing the feasibility of investigating the experimental intervention; determining the experimental treatment's potential efficacy; and investigating mediators and moderators of the experimental treatment. Participants will be adult smokers (N = 50) of at least 10 cigarettes per day with the intention to quit smoking. They will be randomized to one of two conditions: Early Withdrawal Exposure + Withdrawal Regulation Training (E + WT) or Relaxation Training control (RT). The E + WT condition will consist of the development, application, modification, and repeated practice of individualized withdrawal regulation strategies (e.g., behavioral and cognitive strategies for allaying withdrawal symptoms) over three separate sessions that will each span the first four hours of abstinence. The RT condition will control for the therapeutic contact received by those in the E + WT condition. While the proposed investigation is expected to prove feasible, the proposed pilot study will provide an array of data critical to the advancement of the study design, recruitment and retention strategies, and treatment protocol, which includes the treatment manuals. Furthermore, outcome data will allow for the refinement of effect size estimates of the experimental intervention. Finally, candidate mediators (e.g., withdrawal symptoms) and moderators (e.g., tobacco dependence) will be investigated via established analyses. These data will advance the experimental intervention with a focus on targeting mechanisms of change as well as participant characteristics to which the intervention may be tailored. The experimental intervention described in the current application has the potential to ultimately enhance the efficacy of existing smoking cessation interventions and will therefore contribute uniquely to the field.

描述（由申请人提供）：在美国，吸烟仍然是死亡和发病的唯一最可预防的原因。即使是最严格的戒烟治疗，长期戒烟率也在20%到35%之间。因此，继续研究新的戒烟干预措施至关重要。相当多的证据表明，戒断过程形成了吸烟的动机基础，并在复吸中起着关键作用。虽然尼古丁戒断或药理学戒断可能限于10天，但吸烟行为戒断或行为戒断可能无限期持续。因此，有人建议，可以通过帮助吸烟者实施戒断调节策略来加强戒烟干预。本研究的主要目的是试验一种体内早期戒断暴露与戒断调节训练干预戒烟。具体目标包括：告知研究实验干预的可行性;确定实验治疗的潜在功效;并研究实验治疗的介体和调节剂。受试者将是成年吸烟者（N = 50），每天至少吸烟10支，有意戒烟。他们将被随机分配到两种条件之一：早期戒断暴露+戒断调节训练（E + WT）或放松训练对照（RT）。E + WT条件将包括个性化戒断调节策略的开发、应用、修改和重复实践（例如，减轻戒断症状的行为和认知策略）在三个独立的会议上进行，每个会议将跨越前四个小时的禁欲。RT条件将控制E + WT条件下患者接受的治疗接触。虽然拟议的研究预计将证明是可行的，但拟议的试点研究将提供一系列对研究设计、招募和保留策略以及治疗方案（包括治疗手册）的进步至关重要的数据。此外，结果数据将允许细化实验干预的效应量估计。最后，候选调解人（例如，戒断症状）和调节剂（例如，烟草依赖）将通过既定的分析进行调查。这些数据将推进实验性干预，重点是针对变化机制以及干预可能针对的参与者特征。本申请中描述的实验干预具有最终增强现有戒烟干预的功效的潜力，因此将对该领域做出独特贡献。