RHESUS BREEDING COLONY IN NEPAL AND IMPORTATION TO USA

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 在艾滋病研究、可用作生物武器的传染病疫苗的开发以及生物医学研究的其他各种主题方面，需要满足关键需求的恒河猴(Macaca Mulatta)严重短缺。来自印度的恒河猴具有独特的特征，这些特征在艾滋病疫苗的研究中特别有价值。尽管美国最近扩大了繁殖群体，但这些重要研究动物的短缺实际上正在加剧，这突显了对印度型恒河猴新来源的需求。印度型恒河猴大量存在于尼泊尔的许多地区。根据尼泊尔法律，圈养出生的猕猴的生产和出口是得到批准的。这项提议的目的是通过在尼泊尔发展圈养繁殖群体，解决对用于生物医学研究的印度型猕猴新来源的迫切需求。我们正在开发一个自给自足的殖民地，每年能够向美国供应75只动物，以满足关键的生物医学研究需求。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. There is a severe shortage of rhesus monkeys (Macaca mulatta) required to fulfill critical needs in research on AIDS, on development of vaccines against infectious agents that could be used as biological weapons, and on a wide variety of other topics in biomedical research. Rhesus macaques derived from monkeys of Indian origin have unique characteristics that are particularly valuable in research on the development of AIDS vaccines. Despite the recent expansion of breeding colonies in the United States, the shortage of these important research animals is actually increasing in severity, accentuating the need for new sources of Indian-type rhesus. Indian-type rhesus macaques exist in large numbers throughout many regions of Nepal. The production and exportation of captive born rhesus macaques is approved under Nepalese law. The objective of this proposal is to address the urgent need for a new source of Indian-type rhesus macaques for use in biomedical research by developing a captive breeding colony in Nepal. We are developing a self-sustaining colony capable of supplying 75 animals per year to the US to meet critical biomedical research needs.