CHAGAS DISEASE: AN EMERGING FATAL DISEASE IN TEXAS

恰加斯病：德克萨斯州新出现的致命疾病

• 批准号: 8172687
• 负责人: JOHN L VANDEBERG
• 金额: $ 17.8万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172687
• 关键词: Affect; Animals; Blood; Brazil; Chagas Disease; Computer Retrieval of Information on Scientific Projects Database; Diagnostic; Diagnostic Procedure; Disease; Disease Progression; Funding; Genetic; Goals; Grant; Health; Heart; Heart Diseases; Housing; Human; Insecta; Institution; Latin America; Modeling; Monkeys; Morbidity - disease rate; Parasites; Pathology; Population; Research; Research Personnel; Resources; Rural; Source; Texas; United States National Institutes of Health; Work; human subject; mortality; nonhuman primate; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goals of this project are to generate tools and population resources for research on Chagas disease in human subjects and nonhuman primate models. Chagas disease affects 16-18 million people in Latin America, where it is the most prevalent cause of morbidity and mortality from heart disease. Chagas disease is an emerging disease in the US. Nonhuman primates housed in outdoor caging in southern US are naturally exposed to the insects that carry the disease-causing parasite and 2-10% of animals at the SNPRC are infected (percentage dependent on species). The grant provides bridge funding for an NIH grant on the genetics of Chagas disease in a human population in rural Brazil. It also funds the establishment of sensitive PCR diagnostic methods, the genetic characterization of the parasites endemic to Texas, the determination of feasibility of transporting infected blood from human subjects in Brazil to Texas for diagnostic work on the parasites, and assessment of disease progression by determining pathology in hearts from infected monkeys that die spontaneously or are euthanized for health reasons.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该项目的目标是为人类受试者和非人类灵长类动物模型中的chagas病研究生成工具和人口资源。 夏加斯病在拉丁美洲影响16-1800万人，这是心脏病发病和死亡率最普遍的原因。 查加斯病是美国的一种新兴疾病。 在美国南部，内部室外笼中容纳的非人类灵长类动物自然暴露于携带引起疾病的寄生虫的昆虫，而SNPRC中有2-10％的动物被感染（取决于物种的百分比）。 该赠款为巴西农村人口中的人口中的chagas病遗传学提供了NIH赠款的桥梁资金。 它还为建立敏感的PCR诊断方法，寄生虫特有的遗传表征，得克萨斯州特有的遗传表征，确定从巴西在人类受试者到德克萨斯州对寄生虫的诊断工作的可行性的确定，以及通过确定疾病进展的疾病进展的诊断性工作，以确定自发性的病理因素或生病因素。