ANATOMY OF PRIMATE AMYGDALOID COMPLEX

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 灵长类杏仁核是一个复杂的大脑区域，由位于内侧颞叶吻部的13个核团和皮质区组成。这笔赠款资助了以确定猕猴杏仁复合体的细胞结构组织以及内在和外在联系为首要目标的研究。我们也一直在研究自闭症杏仁核的神经病理学。我们报道(Schumann等人，2004年)，在典型发育中的男孩，杏仁核在7到18岁之间经历了40%的体积增加。这种扩张发生在大脑体积减少约10%的时候。在患有自闭症的男孩中，杏仁核在7岁时达到成年大小，此后不会增加。鉴于杏仁核与包括焦虑、抑郁、自闭症和精神分裂症在内的各种精神疾病的关联，其中许多首次出现在青春期周围时期，确定杏仁核出生后发育的形态特征将是有价值的。然而，这是不可行的， 在死后的人脑中进行这种类型的分析。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The primate amygdala is a complex brain region comprised of 13 nuclei and cortical regions in the rostral portion of the medial temporal lobe. This grant has funded studies with the overarching goal of defining the cytoarchitectonic organization and intrinsic and extrinsic connections of the macaque monkey amygdaloid complex. We have also been investigating neuropathology in the autistic amygdala. We reported (Schumann et al, 2004) that the amygdala in typically developing boys undergoes a 40% increase in volume between 7 and 18 years of age. This expansion occurs at a time when the cerebral volume decreases by about 10%. In boys with autism, the amygdala reaches its adult size by 7 years and does not increase thereafter. Given the association of the amygdala with a variety of psychiatric disorders including anxiety, depression, autism and schizophrenia, many of which are first manifest during the peripubertal period, it would be valuable to determine the morphological features of the amygdala's postnatal development. It is not feasible, however, to carry out this type of analysis in postmortem human brains.