NEUROBIOLOGY OF PRIMATE SOCIAL BEHAVIOR

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 该项目的具体目标如下： 具体目标1  继续研究在两周龄时接受鹅膏蕈氨酸杏仁核或海马损伤的猴子的社会情感发育。 具体目标2  评价在两周龄时接受鹅膏蕈氨酸杏仁核或海马损伤的猴的性行为和母性行为。 具体目标3  采用恐惧强化惊吓和前脉冲抑制等听觉惊吓任务，探讨杏仁核永久性损伤和短暂性失活对恐惧行为各成分加工的影响。 具体目标4  利用microPET成像检查成年和幼年猴杏仁核鹅膏蕈氨酸损伤引起的脑可塑性。 具体目标5  使用microPET成像研究在二元社会互动期间婴儿期接受杏仁核损伤的动物增加恐惧行为的潜在神经基质，以及杏仁核损伤的成年动物增加社会行为的潜在神经基质。 具体目标6  利用遗传学方法对杏仁核进行可逆性失活，以复制永久性杏仁核损伤对社会情绪行为的影响。 具体目标7  在当前资助期间，使用研究猕猴社会行为的方案，研究额叶两个区域在社会行为中的作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Specific Aims of this project are as follows: Specific Aim 1  To continue investigations of the socioemotional development of monkeys who received ibotenic acid lesions of the amygdala or hippocampus at two weeks of age. Specific Aim 2  To evaluate the sexual and maternal behavior in monkeys who received ibotenic acid lesions of the amygdala or hippocampus at two weeks of age. Specific Aim 3  To use acoustic startle tasks such as fear potentiated startle and prepulse inhibition to investigate the effect of permanent lesions and transient inactivation of the amygdala on components processes of fear behavior. Specific Aim 4  To use microPET imaging to examine brain plasticity resulting from ibotenic acid lesions of the amygdala in the adult and infant monkeys. Specific Aim 5  To use microPET imaging to investigate potential neural substrates for increased fear behavior by animals who received amygdala lesions as infants during dyadic social interactions and for increased social behavior for adult animals with amygdala lesions. Specific Aim 6  To use a genetic method for reversible inactivation of the amygdala to replicate the effects of permanent amygdala lesions on socioemotional behavior. Specific Aim 7  To use protocols developed to investigate social behavior in the macaque monkey during the current funding period to investigate the roles of two regions of the frontal lobe in social behavior.