ENDOTHELIAL DYSFUNCTION, ADIPOCYTOKINES, INFLAMATION AND CHRONIC KIDNEY DISEASE

内皮功能障碍、脂肪细胞因子、炎症和慢性肾脏病

• 批准号: 8360255
• 负责人: JING CHEN
• 金额: $ 21.39万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8360255
• 关键词: Animal Experiments; Biology; Cardiovascular Diseases; Case-Control Studies; Centers of Research Excellence; Cessation of life; Chronic Kidney Failure; Clinical Research; Early treatment; End stage renal failure; Enrollment; Etiology; Functional disorder; Funding; Grant; Inflammation; Morbidity - disease rate; National Center for Research Resources; Oxidative Stress; Patients; Principal Investigator; Public Health; Renal Hypertension; Research; Research Infrastructure; Resources; Risk; Risk Factors; Role; Source; United States National Institutes of Health; cost; disorder control; follow-up; mortality; novel; premature

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Chronic kidney disease (CKD) has become an important public health challenge in the US. CKD is a major risk factor for end-stage renal disease (ESRD), cardiovascular disease (CVD), and premature death. Understanding novel risk factors for CKD may provide effective approaches for early interventions in order to reduce the morbidity and mortality related to CKD. Endothelial dysfunction, adipocytokines and inflammation have been associated with ESRD and CVD in small clinical studies and animal experiments. However, their role in the etiology of CKD has not been established. The overall objectives of this proposed study are to examine the effects of endothelial dysfunction, adipocytokines, and inflammation on the risk of CKD. We are conducting a case-control study to compare endothelial function, adipocytokines and inflammation between cases with CKD and controls without CKD. We also plan to follow up 200-250 patients who have CKD and already enrolled in the study to examine the longituninal relationship of endothelial dysfunction, oxidative stress, adipocytokines, and inflammation to the risk of CKD.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其他NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 慢性肾脏病（CKD）已成为美国重要的公共卫生挑战。CKD是终末期肾病（ESRD）、心血管疾病（CVD）和过早死亡的主要风险因素。了解CKD的新风险因素可能为早期干预提供有效方法，以降低与CKD相关的发病率和死亡率。在小型临床研究和动物实验中，内皮功能障碍、脂肪细胞因子和炎症与ESRD和CVD相关。 然而，其在CKD病因学中的作用尚未确定。 本研究的总体目标是检测内皮功能障碍、脂肪细胞因子和炎症对CKD风险的影响。我们正在进行一项病例对照研究，以比较CKD病例和非CKD对照之间的内皮功能，脂肪细胞因子和炎症。我们还计划随访200-250例已入组研究的CKD患者，以检查内皮功能障碍、氧化应激、脂肪细胞因子和炎症与CKD风险的长期关系。