SYNTHESIS OF CATIONIC POLYTHIOPHENES TOWARD THERAPEUTIC AGENTS

阳离子聚噻吩的合成用于治疗剂

• 批准号: 8360657
• 负责人: BARRETT EICHLER
• 金额: $ 1.34万
• 依托单位: UNIVERSITY OF SOUTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8360657
• 关键词: Biomedical Research; Chemistry; Complex; DNA; Energy Transfer; Fluorescence Resonance Energy Transfer; Funding; Goals; Grant; Light; Link; Location; National Center for Research Resources; Polymers; Principal Investigator; Quantum Dots; Research; Research Infrastructure; Research Personnel; Resources; Site; Source; South Dakota; Techniques; Therapeutic Agents; United States National Institutes of Health; Universities; absorption; cost; polythiophene

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The goal of this research is to investigate quantum dot-polythiophene-DNA complexes as a means to deliver therapeutic agents to site-specific locations using fluorescence resonance energy transfer (FRET). The FRET technique will be used to induce the release of a therapeutic agent that is attached to a strand of DNA. The use of the quantum dot is to facilitate energy absorption from light at narrow wavelengths and the conducting polymer polythiophene is used as an energy-transfer conduit since quantum dots are difficult to attach to DNA. Initial studies will focus on the energy transfer from the quantum dot to the DNA. Following studies may involve attaching photocleavable groups to any part of the complex. I will collaborate with researchers at the University of South Dakota Chemistry and Biomedical Research Departments and my part is to synthesize polythiophenes that will link the quantum dot and the DNA strand.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 本研究的目的是探讨量子点-聚噻吩-DNA复合物作为一种手段，提供治疗药物的位点特异性位置使用荧光共振能量转移（FRET）。 FRET技术将用于诱导与DNA链连接的治疗剂的释放。 量子点的使用是为了促进来自窄波长光的能量吸收，并且导电聚合物聚噻吩被用作能量传递导管，因为量子点难以附着到DNA。 最初的研究将集中在从量子点到DNA的能量转移上。 以下研究可能涉及将光可裂解基团连接到复合物的任何部分。 我将与南达科他州大学化学和生物医学研究部门的研究人员合作，我的部分是合成将连接量子点和DNA链的聚噻吩。