NEW AND IMPROVED ENDOGENOUS MAGNETIZATION CONTRAST IN MRI

MRI 中新的和改进的内源磁化对比度

• 批准号: 8362005
• 负责人: Anup K. Singh
• 金额: $ 0.77万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362005
• 关键词: Chemicals; Data; Funding; Grant; Image; Individual; Magnetic Resonance; Magnetic Resonance Imaging; National Center for Research Resources; Principal Investigator; Research; Research Infrastructure; Resources; Source; Techniques; United States National Institutes of Health; Water; cost; improved; macromolecule; optical imaging; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. MRI techniques like magnetization transfer (MT), chemical exchange saturation transfer (CEST) and magnetization exchange (ME) are being developed to explore the information about macromolecules and metabolites which cannot be imaged directly due to either ultra-short T2 or very low concentration. Z-spectrum data is used to study these phenomenons. Z-spectrum curve is mixed response of direct saturation (DS) of bulk water, MT, CEST, ME effects; quantification of individual components is essential however, challenging and has been a hot topic of research.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 磁化转移（MT）、化学交换饱和转移（CEST）和磁化交换（ME）等MRI技术正在开发中，以探索大分子的信息 以及由于超短 T2 或极低浓度而无法直接成像的代谢物。 Z 谱数据用于研究这些现象。 Z谱曲线是散装水直接饱和度（DS）、MT、CEST、ME效应的混合响应；然而，单个成分的量化是必要的，具有挑战性，并且一直是研究的热门话题。