ROTATING FRAME RELAXATION MEASUREMENTS IN HUMAN LIVER ON CLINICAL SCANNERS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 细胞外基质(ECM)是肝组织的主要成分，胶原、蛋白多糖、弹性蛋白等大分子是ECM的主要成分。目前，肝组织的有创活检是肝纤维化分期的金标准。虽然使用基于MRI的技术，如MR弹性成像，作为一种非侵入性手段来诊断和分级肝纤维化，已被证明，但它们需要额外的设备来产生剪切波。T1？加权(T1？-W)磁共振成像是一种用于研究不同病理过程中的生化变化的新兴技术。尽管T1？技术在量化与疾病相关的早期大分子变化方面具有巨大潜力，但由于呼吸运动、比吸收率(SAR)以及B0和B1场不均匀等实验挑战，该技术尚未在活体肝组织中被探索。在目前的研究中，我们的目标是开发和实施一种新的T1成像技术，能够在1.5T和3T临床扫描仪上一次屏气绘制肝脏T1成像，而不超过SAR限制。对正常和纤维化的体外组织也进行了T1研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Extracellular matrix (ECM) is the main component of liver tissue and macromolecules like collagen, proteoglycan, elastin etc are major constituents of ECM. Currently, invasive biopsy of the liver tissue is the gold standard for staging liver fibrosis. While the use of MRI based techniques such as MR elastography as a non-invasive means to diagnose and grade hepatic fibrosis has been shown they require additional device for shear wave generation. T1¿-weighted (T1¿-W) MRI is an emerging technique for exploring the biochemical changes in different pathologies. In spite of significant potential of T1¿ technique to quantify early macromolecule changes related to disease, it hasn't been explored in-vivo liver tissue due to experimental challenges such as respiratory motion, specific absorption rate (SAR), and B0 and B1 field in-homogeneities. In the current study, our objective was to develop and implement a novel T1¿ imaging technique capable of T1¿ mapping of liver in a single breath- hold without exceeding SAR limits on 1.5T and 3T clinical scanners. T1¿ study was also carried on ex-vivo tissues both normal and fibrotic.