IN-VIVO CEST IMAGING OF CREATINE

肌酸体内 CEST 成像

• 批准号: 8362007
• 负责人: Anup K. Singh
• 金额: $ 0.77万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362007
• 关键词: Base of the Brain; Binding; Bioenergetics; Brain; Chemicals; Creatine; Disease; Funding; Grant; Image; Magnetic Resonance; Magnetic Resonance Spectroscopy; Maps; Methods; National Center for Research Resources; Play; Principal Investigator; Protons; Rattus; Research; Research Infrastructure; Resolution; Resources; Role; Source; Techniques; United States National Institutes of Health; cost; in vivo; inorganic phosphate; optical imaging; transmission process

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Creatine (Cr) plays an essential role in the storage and transmission of phosphate-bound energy. Because of vital role in the bioenergetics, the brain Cr level has been shown to change almost in all disease conditions. Proton magnetic resonance spectroscopy (1HMRS) is most common and widely applicable non-invasive technique used for the quantification of Cr in brain however, is limited to low spatial resolution, currently there are no generally applicable methods available for direct Cr imaging. Here a non-invasive approach for high-resolution mapping of the Cr in rat brain based on the chemical exchange saturation transfer (CEST) technique is demonstrated.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 肌酸（Cr）在磷酸盐结合能量的储存和传输中起着至关重要的作用。 由于在生物能量学中的重要作用，脑Cr水平已被证明几乎在 所有的疾病状况。质子磁共振波谱（1HMRS）是最常见的， 然而，用于定量脑中Cr的广泛适用的非侵入性技术， 由于空间分辨率低，目前还没有普遍适用的方法 用于直接Cr成像。在这里，一种非侵入性的方法，高分辨率映射的铬在大鼠 脑的化学交换饱和转移（CEST）技术的基础上，证明。