IN-VIVO CEST IMAGING OF CREATINE

肌酸体内 CEST 成像

• 批准号: 8362007
• 负责人: Anup K. Singh
• 金额: $ 0.77万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362007
• 关键词: Base of the Brain; Binding; Bioenergetics; Brain; Chemicals; Creatine; Disease; Funding; Grant; Image; Magnetic Resonance; Magnetic Resonance Spectroscopy; Maps; Methods; National Center for Research Resources; Play; Principal Investigator; Protons; Rattus; Research; Research Infrastructure; Resolution; Resources; Role; Source; Techniques; United States National Institutes of Health; cost; in vivo; inorganic phosphate; optical imaging; transmission process

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Creatine (Cr) plays an essential role in the storage and transmission of phosphate-bound energy. Because of vital role in the bioenergetics, the brain Cr level has been shown to change almost in all disease conditions. Proton magnetic resonance spectroscopy (1HMRS) is most common and widely applicable non-invasive technique used for the quantification of Cr in brain however, is limited to low spatial resolution, currently there are no generally applicable methods available for direct Cr imaging. Here a non-invasive approach for high-resolution mapping of the Cr in rat brain based on the chemical exchange saturation transfer (CEST) technique is demonstrated.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 肌酸（CR）在磷酸盐结合能量的存储和传播中起着至关重要的作用。 由于在生物能学中的重要作用，大脑CR水平已显示出几乎变化 所有疾病状况。质子磁共振光谱（1HMR）最常见，并且 但是，广泛适用于用于量化CR大脑中CR的非侵入性技术，但是 仅限于低空间分辨率，目前尚无适用的方法 用于直接CR成像。这里是大鼠中CR高分辨率映射的非侵入性方法 基于化学交换饱和转移（CEST）技术的大脑。