HIGH RESOLUTION IMAGING OF MYO-INSITOL IN ALZHEMIER?S DISEASE PATHOLOGY
阿尔茨海默病病理学中 MYO-INSITOL 的高分辨率成像
基本信息
- 批准号:8362001
- 负责人:
- 金额:$ 0.77万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-06-01 至 2012-05-31
- 项目状态:已结题
- 来源:
- 关键词:APP-PS1Alzheimer&aposs DiseaseBrainBrain PathologyChemicalsDiseaseFundingGlial Cell ProliferationGrantHumanImageInositolMagnetic ResonanceMagnetic Resonance SpectroscopyMapsMonitorMusNational Center for Research ResourcesPathologyPrincipal InvestigatorProtonsResearchResearch InfrastructureResolutionResourcesSourceTechniquesTimeTransgenic OrganismsUnited States National Institutes of HealthWild Type Mousecostoptical imaging
项目摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
Myo-Inositol (MI) is one of the most abundant metabolites present in the human brain. MI is a marker of glial cells proliferation and functions as an osmolyte in brain. The concentration of MI has been shown to change in various brain pathologies. Proton magnetic resonance spectroscopy (1HMRS) studies have shown increased MI concentration in Alzheimer's disease (AD). Glial cells proliferation/activation is associated with the pathological changes in AD. 1HMRS has been widely used to monitor MI changes in AD, however, it suffers from poor resolution and also does not provide information about the region with the higher glial cells proliferation/activation. Recently, high-resolution mapping of MI in human brain has been performed by exploiting exchangeable OH protons present on MI using a technique commonly known as chemical exchange saturation transfer imaging (CEST). In the current study, for the first time we perform MI CEST on transgenic AD mice (APP/PS1) to evaluate the changes in MI concentration compared to wild type mice.
这个子项目是许多利用资源的研究子项目之一
由NIH/NCRR资助的中心拨款提供。子项目的主要支持
而子项目的主要调查员可能是由其他来源提供的,
包括其它NIH来源。 列出的子项目总成本可能
代表子项目使用的中心基础设施的估计数量,
而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。
肌肌醇(MI)是存在于人脑中最丰富的代谢物之一。MI是神经胶质细胞增殖的标志物,在脑中起渗透剂的作用。MI的浓度已被证明在各种脑病理中发生变化。质子磁共振波谱(1HMRS)研究表明,阿尔茨海默病(AD)中MI浓度增加。胶质细胞的增殖/活化与AD的病理改变有关。1HMRS已被广泛用于监测AD中MI的变化,然而,其分辨率较差,并且也不能提供关于具有较高胶质细胞增殖/活化的区域的信息。最近,已经通过利用可交换的微阵列进行了人脑中MI的高分辨率映射。 使用通常称为化学交换饱和转移成像(CEST)的技术检测MI上存在的OH质子。在本研究中,我们首次对转基因AD小鼠(APP/PS1)进行MI CEST,以评估与野生型小鼠相比MI浓度的变化。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Mohammad Haris其他文献
Mohammad Haris的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Mohammad Haris', 18)}}的其他基金
ASSESSMENT OF CEST EFFECTS IN MYOCARDIAL TISSUE AT 7T
7T 时 CEST 对心肌组织的影响评估
- 批准号:
8362000 - 财政年份:2011
- 资助金额:
$ 0.77万 - 项目类别:
CEST EFFECT FROM PHOSPHO-CREATINE (PCR) AND ADENOSINE-TRI-PHOSPHATE (ATP)
磷酸肌酸 (PCR) 和三磷酸腺苷 (ATP) 的 CEST 效应
- 批准号:
8362002 - 财政年份:2011
- 资助金额:
$ 0.77万 - 项目类别: