ASSESSMENT OF CEST EFFECTS IN MYOCARDIAL TISSUE AT 7T

7T 时 CEST 对心肌组织的影响评估

• 批准号: 8362000
• 负责人: Mohammad Haris
• 金额: $ 2.31万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362000
• 关键词: Bioenergetics; Cardiac; Chemicals; Chronic; Creatine Kinase MB Isoenzyme; Development; Family suidae; Funding; Grant; Image; Imaging Techniques; Infarction; Investigation; Kinetics; Left; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Methodology; Modeling; Morphology; Myocardial Infarction; Myocardial tissue; Myocardium; National Center for Research Resources; Pathology; Principal Investigator; Procedures; Protons; Recovery; Reperfusion Therapy; Research; Research Infrastructure; Resources; Source; Techniques; Tissues; United States National Institutes of Health; Ventricular; cost; inorganic phosphate; optical imaging

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. It is important to distinguish non-infarcted viable myocardial tissue from infarcted tissue in order to determine preoperatively the benefit of a revascularization procedure. Dysfunctional, but viable myocardium has potential for contractile recovery after reperfusion. Developments over the past two decades have established MRI and MR spectroscopy (MRS) as powerful techniques for investigation of cardiac dynamics, morphology, and bioenergetics. Using 31Phosphorus MRS, myocardial creatine kinase (CK) kinetics, high energy phosphate compounds are detected. We hypothesize that chemical exchange saturation transfer (CEST) contrast arising from exchangeable protons (-NH, -NH2 and OH) from different metabolites present in the myocardial tissue may vary between normal and infarcted regions and cardiac CEST MRI may be a viable new methodology for imaging of such pathology. In the current study, we used a combination of an experimental swine model of chronic left ventricular myocardial infarction and CEST imaging technique to demonstrate the feasibility of detecting infarcted and non-infarcted regions.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 重要的是区分非梗死性存活心肌组织和梗死性心肌组织，以便在术前确定血管重建术的益处。功能失调，但有生存能力 心肌在再灌流后有收缩恢复的潜力。过去的发展 二十年来，核磁共振和核磁共振波谱(MRS)已成为 心脏动力学、形态学和生物能量学的研究。使用31Phosorus MRS， 检测心肌肌酸激酶(CK)动力学、高能磷酸化合物。我们 假设化学交换饱和转移(CEST)对比产生于 来自心肌中不同代谢物的可交换质子(-NH、-NH2和OH) 正常和梗死区的组织可能不同，心脏CEST MRI可能是一种可行的新方法来对这种病理进行成像。在目前的研究中，我们使用了一种 猪慢性左室心肌梗死模型及CEST显像 技术证明了检测梗死区和非梗死区的可行性。