SYNTHESIS OF DOPA-MODIFIED PEG

多巴修饰 PEG 的合成

• 批准号: 8361231
• 负责人: John R. Murphy
• 金额: --
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361231
• 关键词: Adhesions; Adhesives; Amino Acids; Area; Bacteria; Binding; Biocompatible; Biocompatible Coated Materials; Cells; Characteristics; Dopa; Environment; Funding; Goals; Grant; Marines; Medical; Metals; Mussels; National Center for Research Resources; Polymers; Principal Investigator; Proteins; Research; Research Infrastructure; Resistance; Resources; Safety; Semiconductors; Source; Surface; Tissue Adhesives; United States National Institutes of Health; Water; aqueous; cost; design; improved; interfacial; novel

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Marine mussels are known to anchor themselves to underwater surfaces in turbulent intertidal zones. They secrete adhesive proteins that can rapidly cure to form adhesive plaques. It is believed that 3,4-dihydroxyphenylalanine (DOPA), an amino acid found in MAPs at a content as much as 25 mol%, is responsible for both strong interfacial binding and curing of these proteins. The goals of our research are to combine the water-resistant adhesive characteristics of DOPA and its derivatives with biocompatible, synthetic polymer for different biomedical applications. One aspect of our research is to design DOPA-modified polymers for the use as tissue adhesive or sealant, which exploits DOPA's ability to cure rapidly and to adhere to a wide variety of surfaces in an aqueous environment. Through the use of different synthetic polymers, it is possible to create novel bioadhesives with improved characteristics (i.e. water-resistant adhesion, biodegradability, and safety) as compared to existing medical adhesives. Another research area focuses on combining DOPA with antifouling polymers to create coating materials that can repel proteins, cells, and bacteria. These coatings can render different surfaces resistant to cell and bacteria adhesion ranging from metals, semiconductors, and synthetic polymers.

这个子项目是利用这些资源的众多研究子项目之一