MULTIPLEXED ANALYSIS OF INFLUENZA VIRUS TYPE, SUB-TYPE, & RECEPTOR SPECIFICITY

流感病毒类型、亚型、

• 批准号: 8361855
• 负责人: ROBERT J WOODS
• 金额: $ 0.18万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-02-01 至 2012-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361855
• 关键词: Antibodies; Avian Influenza; Basic Science; Biological Assay; Flu virus; Funding; Grant; Human; Immunoassay; Measurement; National Center for Research Resources; Phenotype; Principal Investigator; Research; Research Infrastructure; Resources; Source; Specificity; United States National Institutes of Health; Virus; base; carbohydrate receptor; cost; influenzavirus; preference; receptor; receptor binding; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. In order to facilitate the characterization of flu virus for both basic research and surveillance, we have developed a multiplexed microparticle-based assay for simultaneous antibody-based strain typing and sub-typing, as well characterization of carbohydrate receptor binding preference. The combination of immunoassay-based virus sub-typing and receptor binding phenotype measurements provides an important new tool in tracking the adaptation of avian flu strains to human hosts.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 为了促进流感病毒的表征用于基础研究和监测，我们已经开发了一种基于多重微粒的检测方法，用于同时进行基于抗体的毒株分型和亚型分型，以及表征碳水化合物受体结合偏好。基于免疫测定的病毒亚型和受体结合表型测量的组合为追踪禽流感毒株对人类宿主的适应提供了重要的新工具。