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ROSETTA BASED MODELING OF CRYO-EM MAP

ROSETTA BASED MODELING OF CRYO-EM MAP
基于 ROSETTA 的冷冻电镜图建模
批准号：
8361083
负责人：
DAVID BAKER
金额：
$4.9万
依托单位：
BAYLOR COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
项目状态：
已结题
起止时间：
2011-01-01 至 2011-12-31
来源：
https://reporter.nih.gov/project-details/8361083
关键词：
Cryoelectron MicroscopyElectron MicroscopyFundingGrantMapsMethodsModelingNational Center for Research ResourcesPrincipal InvestigatorResearchResearch InfrastructureResolutionResourcesSourceUnited States National Institutes of Healthbasecostdensitymacromoleculerestraint

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中文摘要
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英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. CryoEM is capable of resolving density map to 3.5 to 5 Angstrom resolution. A challenge is to build robust and accurate model. We are exploring the use of Rosetta with cryoEM map restraints to optimize initial model which was built by a variety of methods.
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