SPATIALLY-MODULATED NEAR-INFRARED LIGHT FOR IMAGE-GUIDED ONCOLOGIC SURGERY

用于图像引导肿瘤手术的空间调制近红外光

• 批准号: 8362635
• 负责人: John V Frangioni
• 金额: $ 2.96万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362635
• 关键词: Biomedical Technology; Biotechnology; California; Cardiac; Funding; Grant; Image; Institutes; Laboratories; Lasers; Light; Measurement; Medical; National Center for Research Resources; Operative Surgical Procedures; Principal Investigator; Research; Research Infrastructure; Resources; Source; Surgeon; Surgical Oncology; Technology; Time; United States National Institutes of Health; Universities; base; cost; improved; novel; programs; respiratory; spectroscopic imaging

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. In this application, we propose the use of spatially-modulated NIR light (SMNL) to produce quantitative imaging of ¿¿A, ¿¿S', and QY in essentially real-time. The Modulated Imaging group at the Beckman Laser Institute of the University of California, Irvine, has pioneered the use of this technology for quantitative, depth-resolved spectroscopic imaging as part of the NIH Biomedical Technology Center, the Laser Microbeam and Medical Program (LAMMP) at the Beckman Laser Institute (www.bli.uci.edu/lammp). Recent results shown in Preliminary Studies suggest that SMNL can now be optimized for use over a large surgical field without the need for a laser excitation source. When combined with a novel LED-based light source proposed in this study, and recent advances in cardiac and respiratory gating technology from the PI's laboratory, SMNL should be able to provide surgeons with direct measurement of ¿¿A, ¿¿S', and QY, and thus improve virtually all image-guided surgical interventions.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 在这个应用中，我们建议使用空间调制的近红外光(SMNL)来产生基本上实时的A、S和QY的定量成像。加州大学欧文分校贝克曼激光研究所的调制成像小组率先使用这项技术进行定量、深度分辨光谱成像，这是美国国立卫生研究院生物医学技术中心贝克曼激光研究所激光微束和医学计划(LAMP)的一部分(www.bli.uci.edu/lamp)。初步研究的最新结果表明，SMNL现在可以优化用于大范围的手术领域，而不需要激光激发源。结合本研究中提出的基于LED的新型光源，以及PI实验室在心脏和呼吸门控技术方面的最新进展，SMNL应该能够为外科医生提供A、S和QY的直接测量，从而改进几乎所有图像引导的外科干预措施。