SPATIALLY-MODULATED NEAR-INFRARED LIGHT FOR IMAGE-GUIDED ONCOLOGIC SURGERY

用于图像引导肿瘤手术的空间调制近红外光

• 批准号: 8362635
• 负责人: John V Frangioni
• 金额: $ 2.96万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362635
• 关键词: Biomedical Technology; Biotechnology; California; Cardiac; Funding; Grant; Image; Institutes; Laboratories; Lasers; Light; Measurement; Medical; National Center for Research Resources; Operative Surgical Procedures; Principal Investigator; Research; Research Infrastructure; Resources; Source; Surgeon; Surgical Oncology; Technology; Time; United States National Institutes of Health; Universities; base; cost; improved; novel; programs; respiratory; spectroscopic imaging

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. In this application, we propose the use of spatially-modulated NIR light (SMNL) to produce quantitative imaging of ¿¿A, ¿¿S', and QY in essentially real-time. The Modulated Imaging group at the Beckman Laser Institute of the University of California, Irvine, has pioneered the use of this technology for quantitative, depth-resolved spectroscopic imaging as part of the NIH Biomedical Technology Center, the Laser Microbeam and Medical Program (LAMMP) at the Beckman Laser Institute (www.bli.uci.edu/lammp). Recent results shown in Preliminary Studies suggest that SMNL can now be optimized for use over a large surgical field without the need for a laser excitation source. When combined with a novel LED-based light source proposed in this study, and recent advances in cardiac and respiratory gating technology from the PI's laboratory, SMNL should be able to provide surgeons with direct measurement of ¿¿A, ¿¿S', and QY, and thus improve virtually all image-guided surgical interventions.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 在此应用中，我们建议使用空间调制近红外光 (SMNL) 来实时生成 ¿¿A、¡S' 和 QY 的定量成像。加州大学欧文分校贝克曼激光研究所的调制成像小组率先将该技术用于定量、深度分辨光谱成像，作为 NIH 生物医学技术中心、贝克曼激光研究所激光微束和医学项目 (LAMMP) (www.bli.uci.edu/lammp) 的一部分。初步研究中显示的最新结果表明，SMNL 现在可以优化用于大型手术区域，而无需激光激发源。当与本研究中提出的新型 LED 光源以及 PI 实验室在心脏和呼吸门控技术的最新进展相结合时，SMNL 应该能够为外科医生提供“A”、“S”和 QY 的直接测量，从而改善几乎所有图像引导的手术干预。