SPATIALLY-MODULATED NEAR-INFRARED LIGHT FOR IMAGE-GUIDED ONCOLOGIC SURGERY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在这个应用中，我们建议使用空间调制的近红外光(SMNL)来产生基本上实时的A、S和QY的定量成像。加州大学欧文分校贝克曼激光研究所的调制成像小组率先使用这项技术进行定量、深度分辨光谱成像，这是美国国立卫生研究院生物医学技术中心贝克曼激光研究所激光微束和医学计划(LAMP)的一部分(www.bli.uci.edu/lamp)。初步研究的最新结果表明，SMNL现在可以优化用于大范围的手术领域，而不需要激光激发源。结合本研究中提出的基于LED的新型光源，以及PI实验室在心脏和呼吸门控技术方面的最新进展，SMNL应该能够为外科医生提供A、S和QY的直接测量，从而改进几乎所有图像引导的外科干预措施。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this application, we propose the use of spatially-modulated NIR light (SMNL) to produce quantitative imaging of ¿¿A, ¿¿S', and QY in essentially real-time. The Modulated Imaging group at the Beckman Laser Institute of the University of California, Irvine, has pioneered the use of this technology for quantitative, depth-resolved spectroscopic imaging as part of the NIH Biomedical Technology Center, the Laser Microbeam and Medical Program (LAMMP) at the Beckman Laser Institute (www.bli.uci.edu/lammp). Recent results shown in Preliminary Studies suggest that SMNL can now be optimized for use over a large surgical field without the need for a laser excitation source. When combined with a novel LED-based light source proposed in this study, and recent advances in cardiac and respiratory gating technology from the PI's laboratory, SMNL should be able to provide surgeons with direct measurement of ¿¿A, ¿¿S', and QY, and thus improve virtually all image-guided surgical interventions.