TESTOSTERONE THRESHOLD LEVELS AND LEAN TISSUE MASS TARGETS NEEDED TO ENHANCE

需要增强的睾酮阈值水平和瘦肉组织质量目标

• 批准号: 8361463
• 负责人: STANLEY P AZEN
• 金额: $ 1.64万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361463
• 关键词: Aging; Funding; Gel; Grant; Hormonal; Hormones; Masks; Mass Spectrum Analysis; Muscle; National Center for Research Resources; Outcome; Pathway Analysis; Performance; Physical Function; Principal Investigator; Questionnaires; Research; Research Infrastructure; Resources; Skeletal Muscle; Source; Testosterone; Tissues; United States National Institutes of Health; aged; biomedical resource; cost; design; leydig interstitial cell; men; muscle form; muscle metabolism; r-hGH-M

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. BACKGROUND: In the HORMA (Hormonal Regulators of Muscle and Metabolism in Aging) Trial, supplemental testosterone and recombinant human growth hormone (rhGH) enhanced lean body mass, appendicular skeletal muscle mass, muscle performance, and physical function, but there was substantial interindividual variability in outcomes. METHODS: One hundred and twelve men aged 65-90 years received testosterone gel (5 g/d vs 10 g/d via Leydig cell clamp) and rhGH (0 vs 3 vs 5 ¿g/kg/d) in a double-masked 2 ¿ 3 factorial design for 16 weeks. Outcomes included lean tissue mass by dual energy x-ray absorptiometry, one-repetition maximum strength, Margaria stair power, and activity questionnaires. We used pathway analysis to determine the relationship between changes in hormone levels, muscle mass, strength, and function.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 背景：在HORMA(衰老中肌肉和代谢的激素调节)试验中，补充睾酮和重组人生长激素(RhGH)可以增加瘦体重、附件骨骼肌质量、肌肉性能和身体功能，但结果存在很大的个体差异。 方法：112例65~90岁男性患者应用睾酮凝胶(5g/d比10g/d)和重组人生长激素(0g/kg/d和5g/kg/d)，采用双掩蔽2？3析因设计，疗程16周。结果包括双能X射线吸收法测量的瘦组织质量、一次重复最大强度、Margaria阶梯功率和活动问卷。我们使用通径分析来确定激素水平、肌肉质量、力量和功能变化之间的关系。