Training Grant in Genomic Analysis and Interpretation

基因组分析和解释培训补助金

• 批准号: 7067720
• 负责人: STANLEY P AZEN
• 金额: $ 20.79万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7067720
• 关键词: Training; Grant; Genomic; Analysis; Interpretation

DESCRIPTION (provide by applicant) Two trends have dramatically altered the landscape of training in biomedical research. The first is increasing emphasis on multidisciplinary research, requiring investigators to have both depth in their own particular area of expertise, as well as the breadth of skills required to form new liaisons and collaborations with other scientists in diverse fields. The second is the increasing use of sophisticated statistical and computational data analyses, especially of genomic data. Mathematical and computational scientists must be thoroughly engaged in the biological issues of the problems they are working on if they are to be able to communicate with their colleagues and make important contributions. The proposed program will offer new pre-and postdoctoral training in environmental genetics that spans the disciplines of genetic, molecular and environmental epidemiology, statistical genetics, bioinformatics and computational molecular biology. The investigators propose to build upon the historical strength of the (University of Southern California) USC Department of Preventive Medicine in cancer and environmental epidemiology to focus their training on dissecting complex biological pathways involving gene-environment and gene-gene interactions, issues that are central to the NIEHS Environmental Genome Project. The investigators also propose to integrate these training programs based at the Keck School of Medicine more closely with those in the Program in Molecular and Computational Biology located at the University Park Campus, in order to provide training in modern genomics and bioinformatics techniques that are relevant to the NHGRI Human Genome Project and International Haplotype Mapping ("HapMap") Project. The specific aims of this proposal are to provide multidisciplinary training for three pre-doctoral scientists and two postdoctoral scientists in specialized training at the interface between environmental health and genomics. Extensive research resources are available in support of studying gene-environment and gene/gene interactions in cancer and other diseases.

描述(由申请人提供) 两种趋势极大地改变了生物医学研究培训的格局。首先是对多学科研究的日益重视，要求研究人员既要在自己的特定专业领域有深度，又要有与不同领域的其他科学家建立新的联系和合作所需的技能广度。第二是越来越多地使用复杂的统计和计算数据分析，特别是基因组数据。如果数学和计算科学家能够与他们的同事交流并做出重要贡献，他们必须彻底参与到他们正在研究的问题的生物学问题中。 拟议的计划将提供新的环境遗传学博士后和博士后培训，涵盖遗传学、分子和环境流行病学、统计遗传学、生物信息学和计算分子生物学等学科。研究人员建议利用(南加州大学)南加州大学癌症和环境流行病学预防医学系的历史优势，将他们的培训重点放在解剖涉及基因-环境和基因-基因相互作用的复杂生物途径上，这些问题是NIEHS环境基因组计划的核心问题。研究人员还建议将凯克医学院的这些培训项目与位于大学园区校园的分子和计算生物学项目的培训项目更紧密地结合在一起，以便提供与NHGRI人类基因组项目和国际单倍型图谱(HapMap)项目相关的现代基因组学和生物信息学技术方面的培训。 这项建议的具体目标是为三名博士后科学家和两名博士后科学家提供环境健康与基因组学之间的专门培训。广泛的研究资源可用于支持研究癌症和其他疾病中的基因-环境和基因/基因相互作用。