INVESTIGATION OF EFFECT OF DIETARY/ORAL DRUGS ON TRACE ELEMENTS IN PANCREATIC CA

膳食/口服药物对胰腺 CA 微量元素影响的研究

• 批准号: 8362389
• 负责人: ANIRUDDHA DEB
• 金额: $ 0.27万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362389
• 关键词: Cancerous; Cisplatin; Drug Combinations; Funding; Grant; Investigation; Malignant neoplasm of pancreas; Mammary Gland Parenchyma; Metals; Modeling; Mus; National Center for Research Resources; Normal tissue morphology; Oral; Pancreas; Pharmaceutical Preparations; Principal Investigator; Radiation; Research; Research Infrastructure; Resources; Source; Staging; Terminally Ill; Tissue Model; Tissues; Trace Elements; Tumor Tissue; United States National Institutes of Health; Work; chemotherapy; cost; design; structural biology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Our investigation will be concentrating on micro XRF on histological sections of pancreatic cancer tissue of mice as models, to study the changes in the trace elements in the cancerous pancreatic tissues/tumors, starting from normal tissue, model tissue administered Chemotherapy (with Cisplatin), and model tissue that have been on dietary drugs. The investigation will also cover studies on tissues/tumors of different stages of models, starting from initial, intermediate, and terminally ill. The comparison of the changes in the level of metal concentrations (e.g. Zn, Cu, Fe) and their correlation, obtained using the Cisplatin, using the oral drug and combination of Cisplatin and oral drug, will help immensely to understand, how chemically it works in the breast tissue and ultimately help in designing more effective non-toxic drugs.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 我们的研究将集中于以小鼠胰腺癌组织为模型的组织学切片的微型XRF，从正常组织、接受化疗（顺铂）的模型组织和接受饮食药物的模型组织开始，研究癌性胰腺组织/肿瘤中微量元素的变化。该调查还将涵盖对模型不同阶段的组织/肿瘤的研究，从初期、中期和末期开始。使用顺铂、使用口服药物以及顺铂和口服药物的组合获得的金属浓度（例如锌、铜、铁）水平的变化及其相关性的比较将极大地有助于了解其在乳腺组织中的化学作用，并最终有助于设计更有效的无毒药物。