EFFECT OF DIETARY/ORAL DRUGS ON THE TRACE ELEMENTS IN PANCREATIC CANCER TISSUE

膳食/口服药物对胰腺癌组织中微量元素的影响

• 批准号: 8361314
• 负责人: ANIRUDDHA DEB
• 金额: $ 2.17万
• 依托单位: ILLINOIS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361314
• 关键词: Biophysics; Cisplatin; Funding; Grant; Growth; Homeostasis; Image; Malignant - descriptor; Malignant neoplasm of pancreas; Metals; National Center for Research Resources; Oral; Pancreas; Pharmaceutical Preparations; Play; Principal Investigator; Research; Research Infrastructure; Resources; Role; Sampling; Source; Survival Rate; Tissue Model; Tissues; Trace Elements; United States National Institutes of Health; Zinc; base; chemotherapy; cost; malignant breast neoplasm; tumor progression; zinc-binding protein

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The zinc transporter ZIP4 is over expressed in most pancreatic cancer and is a malignant factor in cancer progression. Silencing of ZIP4 is thought to inhibit pancreatic cancer growth and increases the survival rate. Recent studies indicated that zinc transport and zinc homeostasis play important roles in cancer progression, especially in pancreatic cancer and breast cancer. Recent studies have predicted that there might be correlation between metals Zn, Fe and Cu in pancreatic cancer. Based on these recent predictions about trace elements might play an important role in pancreatic cancer. We have performed XRF imaging at BioCAT beam line on pancreatic tissue models (samples were control, Cisplatin chemotherapy treated and oral Drug MI- 219 treated). We have observed an increase of the metal levels with treatment, changes in the ratio of Cu to Zn and Fe to Zn.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 锌转运蛋白ZIP4在大多数胰腺癌中过度表达，是癌症进展中的一种恶性因素。沉默ZIP4被认为可以抑制胰腺癌的生长，提高存活率。最近的研究表明，锌转运和锌稳态在肿瘤进展中起着重要作用，特别是在胰腺癌和乳腺癌中。最近的研究预测，锌、铁和铜在胰腺癌中可能存在相关性。根据这些最近的预测，微量元素可能在胰腺癌中发挥重要作用。我们在BioCAT光束线上对胰腺组织模型(对照组、顺铂化疗组和口服药物MI-219组)进行了XRF成像。我们观察到，随着治疗的进行，金属水平增加，铜与锌、铁与锌的比值发生变化。