EFFECT OF DIETARY/ORAL DRUGS ON THE TRACE ELEMENTS IN BREAST CANCER TISSUE

膳食/口服药物对乳腺癌组织中微量元素的影响

• 批准号: 8361311
• 负责人: ANIRUDDHA DEB
• 金额: $ 1.77万
• 依托单位: ILLINOIS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361311
• 关键词: Biophysics; Caliber; Cancer Patient; Fluorescence; Funding; Goals; Grant; HDPE; Infusion procedures; Investigation; Mammary Gland Parenchyma; Measurement; National Center for Research Resources; Oral; Patients; Pharmaceutical Preparations; Principal Investigator; Research; Research Infrastructure; Resources; Sampling; Source; Tissue Sample; Tissues; Trace Elements; United States National Institutes of Health; chemotherapy; cost; design; gemcitabine; malignant breast neoplasm; tumor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The goal of this investigation is to study the changes and their correlation in the trace elements in the histological sections of breast cancer tissues from patients who are on dietary/oral drugs instead of standard chemotherapy (administered by drip or infusion). For the measurement on breast tissues the samples were mounted on specially designed HDPE rings, with an outer diameter of 12 mm and an inner diameter of 6 mm, using kapton tape. This design allowed the x-ray beam to pass through the sample for recording intensity behind the sample as well as fluorescence. We have evaluated the following samples. 1. Breast tissue from normal patient (control sample). 2. Breast tissue from tumor . 3. Breast tissue from tumor cancer patient after administering gemcitabine chemotherapy (tissue collected after 5 days starting from the day gemcitabine was administered), this is mainly because the first signs of change shows after 5 days. 4. Breast tissue from tumor after 15 days of administering gemcitabine. 5. Breast tissue from tumor from administered dietary/oral drug for 22 days. 6. Breast tissue from tumor after 40 days of dietary/oral drug. We are evaluating the results and we expect to complete the set of measurements in 2011 beamtime.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 本研究的目的是研究饮食/口服药物而不是标准化疗（通过滴注或输注给药）的患者乳腺癌组织的组织切片中微量元素的变化及其相关性。对于乳房组织的测量，使用Kapton胶带将样品安装在专门设计的HDPE环上，外径为12 mm，内径为6 mm。 这种设计允许X射线束穿过样品，用于记录样品后面的强度以及荧光。我们评估了以下样品。1. 正常患者的乳腺组织（对照样本）。 2.肿瘤的乳房组织 3.给予吉西他滨化疗后肿瘤患者的乳腺组织（从给予吉西他滨之日起5天后收集的组织），这主要是因为5天后出现第一个变化迹象。 4.吉西他滨给药15天后肿瘤的乳腺组织。 5.来自给予饮食/口服药物22天的肿瘤的乳腺组织。 6.饮食/口服药物40天后肿瘤的乳腺组织。 我们正在评估结果，我们预计将在2011年完成一套测量。