NEURAL CORRELATES OF EXECUTIVE FUNCTION AND EMOTION IN ADOLESCENCE

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 参加者将是14名20-22岁的成年人和16名13-14岁的青少年。 扫描会话将从矢状定位开始开始，以便规定后续图像。将获取SSTT 1 MPSII图像，用于功能图像的配准。当受试者执行以下行为任务时，将在三次运行中采集全脑EPI BOLD图像。将以相同的分辨率和切片位置采集EPI场图，以允许场不均匀性的离线校正。 行为结合了go/nogo任务与从国际情感图片系统中选择的情感唤起背景图像。在这个任务中，字母顺序地显示在计算机屏幕中央的一个小框中。受试者被要求尽可能快地对一系列字母中的每一个做出反应，除了一个特定的目标：“X”。X出现在25%的试验中，这样参与者就获得了一种强有力的压力倾向，并需要在nogo试验中积极抑制他们的反应。行为任务由三次运行的12个模块组成。将使用MRI兼容按钮盒记录反应（按下或未按下）和反应时间。 我们预计整个会议每个主题需要一个小时。这一估计数包括15分钟的设备安装和与会者就位、11分钟的结构扫描、30分钟的功能扫描和10分钟的清理和数据传输。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Participants will be 14 adults between the ages of 20-22 years and 16 teens between the ages of 13-14 years. The scanning session will begin with a sagittal scout for purposes of prescribing subsequent images. Sagittal T1 MPRAGE images will be aquired for coregistration of functional images. Whole brain EPI BOLD images will be acquired in three runs while subjects perform the behavioral task below. An EPI fieldmap will be acquired at the same resolution and slice locations to allow for offline correction of field inhomogeneities. The behavioral combines a go/nogo task with emotionally arousing background images selected from the International Affective Picture System. In this task, letters are presented sequentially in a small box at the center of the computer screen. Subjects are asked to respond as quickly as possible with a button press to every one of a series of letters except for a specific target: an 'X'. The Xs appear on 25% of trials such that participants acquire a prepotent tendency to press and need to actively inhibit their response during nogo trials. The behavioral task consists of three runs of twelve blocks. Responses (press or no press) and reaction times will be recorded using an MRI compatible button box. We anticipate the entire session taking one hour per subject. This estimate includes 15 minutes for equipment setup and positioning of the participant, 11 minutes of structural scanning, 30 minutes of functional scanning and 10 minutes of clean-up and data transfer.