NEUROPHYSIOLOGIC ASSESSMENT OF AT-RISK NEWBORNS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在该方案中，我们建议继续测试糖尿病母亲(IDM)和健康足月对照组婴儿的婴儿样本。研究中的假设是，缺铁伴或不伴胎儿缺氧可以选择性地损害内侧颞叶中调节外显记忆的结构；因此，我们预测IDM可能面临发展记忆障碍的风险。我们继续专注于使用电生理(事件相关电位)工具和行为评估来评估受试者从新生儿到5岁的听觉和视觉识别记忆。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this protocol we propose to continue testing samples of infants born to diabetic mothers (IDMs) and healthy full-term control infants. The hypothesis under investigation is that iron deficiency with or without fetal hypoxia can selectively damage the structures in the medial temporal lobe that mediate explicit memory; thus, we predict that IDMs may be at risk for developing impairments in memory. We continue to focus on evaluating auditory and visual recognition memory in subjects from newborn through 5 years of age, using electrophysiological (event-related potentials) tools and behavioral assessments.