NEUROPHYSIOLOGIC ASSESSMENT OF AT-RISK NEWBORNS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 在本方案中，我们建议继续检测糖尿病母亲（IDM）所生婴儿和健康足月对照婴儿的样本。 正在调查的假设是，铁缺乏或不胎儿缺氧可以选择性地损害中介外显记忆的内侧颞叶的结构，因此，我们预测，IDM可能有发展中的记忆障碍的风险。 我们继续专注于评估从新生儿到5岁的受试者的听觉和视觉识别记忆，使用电生理（事件相关电位）工具和行为评估。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this protocol we propose to continue testing samples of infants born to diabetic mothers (IDMs) and healthy full-term control infants. The hypothesis under investigation is that iron deficiency with or without fetal hypoxia can selectively damage the structures in the medial temporal lobe that mediate explicit memory; thus, we predict that IDMs may be at risk for developing impairments in memory. We continue to focus on evaluating auditory and visual recognition memory in subjects from newborn through 5 years of age, using electrophysiological (event-related potentials) tools and behavioral assessments.